AC susceptibility of magnetic markers in suspension for liquid phase immunoassay

Keiji Enpuku, Tsuyoshi Tanaka, Yuya Tamai, Masaaki Matsuo

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

AC susceptibility of magnetic markers in solution was studied for biosensor applications. First, frequency dependence of the susceptibility was measured, and size distribution of the markers was estimated by analyzing the experimental result with the so-called singular value decomposition (SVD) method. The size distribution estimated with the magnetic measurement agreed with that obtained from conventional optical measurement. Next, susceptibility measurement was applied to the liquid-phase immunoassay without bound/free (B/F) separation. We performed the detection of biotin-coated polymer beads in suspension using avidin-coated magnetic markers. Changes of the susceptibility and the size distribution caused by the binding reaction were shown.

本文言語英語
ページ(範囲)1621-1624
ページ数4
ジャーナルJournal of Magnetism and Magnetic Materials
321
10
DOI
出版ステータス出版済み - 5 2009

All Science Journal Classification (ASJC) codes

  • 電子材料、光学材料、および磁性材料
  • 凝縮系物理学

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