Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene

Azumi Hamasaki, Fujiro Sendo, Keiko Nakayama, Noriko Ishida, Izumi Negishi, Kei Ichi Nakayama, Shigetsugu Hatakeyama

研究成果: Contribution to journalArticle査読

182 被引用数 (Scopus)

抄録

To elucidate the role of A1, a new member of the Bcl-2 family of apoptosis regulators active in hematopoietic cell apoptosis, we established mice lacking A1-a, a subtype of the A1 gene in mice (Al-a(-/-) mice). Spontaneous apoptosis of peripheral blood neutrophils of A1-a(-/-) mice was enhanced compared with that of either wild-type mice or heterozygous mutants (A1-a(+/-) mice). Neutrophil apoptosis inhibition induced by lipopolysaccharide treatment in vitro or transendothelial migration in vivo observed in wild-type mice was abolished in both A1-a(-/-) and A1-a(+/-) animals. On the other hand, the extent of tumor necrosis factor α-induced acceleration of neutrophil apoptosis did not differ among A1-a(-/-), A1- a(+/-), and wild-type mice. The descending order oral mRNA expression was wild-type, A1-a(+/-), and A1-a(-/-). Taken together, these results suggest that A1 is involved in inhibition of certain types of neutrophil apoptosis.

本文言語英語
ページ(範囲)1985-1992
ページ数8
ジャーナルJournal of Experimental Medicine
188
11
DOI
出版ステータス出版済み - 12 7 1998

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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