Accentuation by pertussis toxin of the 5-hydroxytryptamine-induced potentiation of ATP-evoked responses in rat pheochromocytoma cells

Schuichi Koizumi, Makoto Ikeda, Ken Nakazawa, Kaori Inoue, Kunisuke Nagamatsu, Akira Hasegawa, Kazuhide Inoue

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

We previously demonstrated that 5-hydroxytryptamine (5-HT) enhances the cationic current activated by extracellular ATP in rat pheochromocytoma PC12 cells. We report here that pertussis toxin (PTX) modulates this 5-HT-dependent enhancement in these cells. 5-HT potentiated ATP-evoked intracellular Ca2+ concentration ([Ca]i) rise and dopamine release over a concentration range from 1 to 100 μM. When cells were pre-treated with PTX, this potentiation was accentuated. Pretreatment with PTX also accentuated the 5-HT dependent enhancement of the ATP-activated current. These results suggest that the enhancement by 5-HT of the ATP-evoked responses is negatively regulated by a mechanism mediated through PTX-sensitive GTP-binding protein.

本文言語英語
ページ(範囲)104-107
ページ数4
ジャーナルNeuroscience Letters
183
1-2
DOI
出版ステータス出版済み - 1 2 1995
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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