Accumulation of αB-crystallin in brains of patients with Alexander's disease is not due to an abnormality of the 5′-flanking and coding sequence of the genomic DNA

Akiko Iwaki, Toru Iwaki, James E. Goldman, Koji Ogomori, Jun Tateishi, Yoshiyuki Sakaki

研究成果: Contribution to journalArticle

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抜粋

αB-Crystallin is a major protein component of Rosenthal fibers, which massively accumulate in the brains of patients suffering from Alexander's disease. To examine whether or not accumulation of αB-crystallin is due to any abnormality of the gene structures, we determined the sequence of the αB-crystallin gene in two cases of pathologically confirmed Alexander's disease. Direct sequencing of the promoter and coding regions of the αB-crystallin gene in patients revealed them to have a normal sequence. Northern blotting showed a single αB-crystallin mRNA species expressed in the Alexander's disease brain.

元の言語英語
ページ(範囲)89-92
ページ数4
ジャーナルNeuroscience Letters
140
発行部数1
DOI
出版物ステータス出版済み - 6 8 1992

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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