Accumulation of human T lymphotropic virus type I-infected T cells in the salivary glands of patients with human T lymphotropic virus type I- associated Sjogren's syndrome

Yukiko Ohyama, Seiji Nakamura, Hideo Hara, Masanori Shinohara, Masanori Sasaki, Akiko Ikebe-Hiroki, Takefumi Mouri, Shizuka Tsunawaki, Kihachiro Abe, Kanemitsu Shirasuna, Kikuo Nomoto

研究成果: Contribution to journalArticle査読

27 被引用数 (Scopus)

抄録

Objective. To clarify the involvement of human T lymphotropic virus type I (HTLV-I) in the pathogenesis of Sjogren's syndrome (SS). Methods. In HTLV- I-seropositive patients with SS, HTLV-I proviral DNA in the labial salivary glands (SG) was detected by polymerase chain reaction (PCR) amplification of the extracted cellular DNA, and the localization in the SG was examined by in situ PCR hybridization. Results. The cellular DNA extracted from the SG contained full HTLV-I proviral DNA, which was present in the nucleus of the infiltrating T cells, but not in either the SG epithelial cells or the acinar cells. Furthermore, the viral loads in the SG were ~8 times to 9 x 103 times higher than those in the peripheral blood mononuclear cells. Conclusion. Accumulation of HTLV-I-infected T cells in the SG suggests that HTLV-I likely causes the self-reactive T cells to proliferate, which, as a result, induces SS.

本文言語英語
ページ(範囲)1972-1978
ページ数7
ジャーナルArthritis and rheumatism
41
11
DOI
出版ステータス出版済み - 11 17 1998

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

フィンガープリント 「Accumulation of human T lymphotropic virus type I-infected T cells in the salivary glands of patients with human T lymphotropic virus type I- associated Sjogren's syndrome」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル