Accumulation of MDM2 in pleomorphic xanthoastrocytomas

Kenichi Matsumoto, Satoshi O. Suzuki, Masashi Fukui, Toru Iwaki

研究成果: Contribution to journalArticle

8 被引用数 (Scopus)

抄録

The molecular genetic basis and the tumorigenic mechanism of pleomorphic xanthoastrocytoma (PXA) still remain to be elucidated. The amplification of the mdm2 gene and accumulation of the MDM2 protein, which is considered to be one of the major cellular regulators of p53-mediated cell growth control, were studied in eight specimens of PXA obtained from five patients. All of the PXA samples showed at least focal immunopositivity for MDM2. However, none of the samples showed mdm2 gene amplification. These results suggest that accumulation of MDM2 without gene amplification may be one of the major molecular events occurring in the tumorigenesis of PXA.

本文言語英語
ページ(範囲)387-391
ページ数5
ジャーナルPathology International
54
6
DOI
出版ステータス出版済み - 6 2004

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

フィンガープリント 「Accumulation of MDM2 in pleomorphic xanthoastrocytomas」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル