Accumulation of MDM2 in pleomorphic xanthoastrocytomas

Kenichi Matsumoto, Satoshi Suzuki, Masashi Fukui, Toru Iwaki

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

抄録

The molecular genetic basis and the tumorigenic mechanism of pleomorphic xanthoastrocytoma (PXA) still remain to be elucidated. The amplification of the mdm2 gene and accumulation of the MDM2 protein, which is considered to be one of the major cellular regulators of p53-mediated cell growth control, were studied in eight specimens of PXA obtained from five patients. All of the PXA samples showed at least focal immunopositivity for MDM2. However, none of the samples showed mdm2 gene amplification. These results suggest that accumulation of MDM2 without gene amplification may be one of the major molecular events occurring in the tumorigenesis of PXA.

元の言語英語
ページ(範囲)387-391
ページ数5
ジャーナルPathology International
54
発行部数6
DOI
出版物ステータス出版済み - 6 1 2004

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Gene Amplification
Molecular Biology
Carcinogenesis
Growth
Proteins

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

これを引用

Accumulation of MDM2 in pleomorphic xanthoastrocytomas. / Matsumoto, Kenichi; Suzuki, Satoshi; Fukui, Masashi; Iwaki, Toru.

:: Pathology International, 巻 54, 番号 6, 01.06.2004, p. 387-391.

研究成果: ジャーナルへの寄稿記事

Matsumoto, Kenichi ; Suzuki, Satoshi ; Fukui, Masashi ; Iwaki, Toru. / Accumulation of MDM2 in pleomorphic xanthoastrocytomas. :: Pathology International. 2004 ; 巻 54, 番号 6. pp. 387-391.
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