Accumulation of Neurofilaments in a Sporadic Case of Amyotrophic Lateral Sclerosis

Akira Kondo, Toru Iwaki, Jun Tateishi, Kohji Kirimoto, Tadao Morimoto, Ichirou Oomura

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

抄録

Abstract: We report a case of sporadic amyotrophic lateral sclerosis (ALS) characterized by a marked accumulation of neurofilaments in the cytoplasm of neurons. The neurofilament was identified by immunohistochemical and electron microscopic studies. The distribution of the accumulation in this case was unique, not only in the motoneurons of the anterior horn but also in the neurons of the other areas of the spinal gray matter, some nuclei in the brain stem, pontine reticular formation, substantia nigra, dentate nucleus in the cerebellum and pyramidal cells in the motor cortex. These observations shed light on the pathogenesis of ALS.

元の言語英語
ページ(範囲)677-684
ページ数8
ジャーナルPsychiatry and clinical neurosciences
40
発行部数4
DOI
出版物ステータス出版済み - 12 1986

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Intermediate Filaments
Neurons
Cerebellar Nuclei
Pyramidal Cells
Amyotrophic Lateral Sclerosis
Motor Cortex
Motor Neurons
Substantia Nigra
Horns
Cerebellum
Brain Stem
Cytoplasm
Electrons
Amyotrophic lateral sclerosis 1
Gray Matter
Pontine Tegmentum

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

これを引用

Accumulation of Neurofilaments in a Sporadic Case of Amyotrophic Lateral Sclerosis. / Kondo, Akira; Iwaki, Toru; Tateishi, Jun; Kirimoto, Kohji; Morimoto, Tadao; Oomura, Ichirou.

:: Psychiatry and clinical neurosciences, 巻 40, 番号 4, 12.1986, p. 677-684.

研究成果: ジャーナルへの寄稿記事

Kondo, Akira ; Iwaki, Toru ; Tateishi, Jun ; Kirimoto, Kohji ; Morimoto, Tadao ; Oomura, Ichirou. / Accumulation of Neurofilaments in a Sporadic Case of Amyotrophic Lateral Sclerosis. :: Psychiatry and clinical neurosciences. 1986 ; 巻 40, 番号 4. pp. 677-684.
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