Accumulation of oligoclonal T cells in the infiltrating lymphocytes in oral lichen planus

E. Kawamura, Seiji Nakamura, M. Sasaki, Yukiko Ohyama, T. Kadena, Kumamaru Wataru, K. Shirasuna

研究成果: Contribution to journalArticle査読

27 被引用数 (Scopus)

抄録

Background: Identification of a disease-specific and possibly pathogenic T-cell receptor (TCR) in oral lichen planus (OLP) is one of the most important steps to reveal the pathogenic antigen recognized by the T cells and thereby elucidate the pathogenesis and etiology of OLP. Methods: In buccal mucosa biopsy specimens and peripheral blood mononuclear cells (PBMC) from seven patients with OLP, the TCR Vβ gene usage was examined by polymerase chain reaction-based and single-strand conformation polymorphism analyses. Results: The Vβ families expressed in the biopsy specimens were markedly heterogeneous, but they were restricted in comparison to those observed in the PBMC. The Vβ families predominantly expressed in the biopsy specimens in comparison with the PBMC were still heterogeneous in individual patients and differed from patient to patient; however, Vβ2, Vβ6, and Vβ19 were commonly predominant in the biopsy specimens from more than half of the patients. Among the Vβ families predominantly expressed in the biopsy specimens, the accumulation of T-cell clonotypes was observed in the majority of the Vβ families including Vβ6 and Vβ19; however, it was not observed in the minority of the Vβ families including Vβ2. Conclusions: These results suggest that unique T-cell populations bearing Vβ2, Vβ6, or Vβ19 gene products tend to expand in OLP lesions as a consequence of in situ stimulation with a restricted epitope of either a nominal antigen on the MHC molecule for the majority of the Vβ families, even if only in minor populations, or of a common superantigen for the minority of the Vβ families.

本文言語英語
ページ(範囲)282-289
ページ数8
ジャーナルJournal of Oral Pathology and Medicine
32
5
DOI
出版ステータス出版済み - 1 1 2003

All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 口腔外科
  • 耳鼻咽喉科学
  • 癌研究
  • 歯周病学

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