Accuracy of amplitude-based respiratory gating for PET/CT in irregular respirations

Yuji Tsutsui, Daisuke Kidera, Takafumi Taniguchi, Go Akamatsu, Isao Komiya, Yoshiyuki Umezu, Yoshiyuki Kitamura, Shingo Baba, Masayuki Sasaki

研究成果: Contribution to journalArticle査読

7 被引用数 (Scopus)

抄録

Objective: We evaluated the accuracy of amplitude gating PET (AG-PET) compared with phase gating PET (PG-PET) in relation to respiratory motion patterns based on a phantom analysis.

Method: We used a NEMA IEC body phantom filled with an 18F solution with a 4:1 sphere-to-background radioactivity ratio (12.6 and 2.97 kBq/mL). PET/CT scans were acquired in a motionless and moving state on a Biograph mCT. The respiratory movements were simulated by four different waveform patterns consisting of ideal breathing, breathing with a pause period, breathing with a variable amplitude and breathing with a changing baseline. AG-PET selects the narrow bandwidth containing 20 % of the respiratory cycle. PG-PET was reconstructed with five gates. The image quality was physically assessed using the percent contrast (QH,10mm), background variability (N10mm) recovery coefficient (RC), and sphere volumes.

Result: In regular motion patterns with ideal breathing and breathing with a pause period, the QH,10mm, RC and sphere volumes were not different between AG-PET and PG-PET. In the variable amplitude pattern, the QH,10mm of AG-PET was higher than that of PG-PET (35.8 vs 28.2 %), the RC of AG-PET was higher than that of PG-PET and sphere volume of AG-PET was smaller than that of PG-PET (6.4 vs 8.6 mL). In the changing baseline pattern, the QH,10mm of AG-PET was higher than that of PG-PET (42.4 vs 16.7 %), the RC of AG-PET was higher than that of PG-PET and sphere volume of AG-PET was smaller than that of PG-PET (6.2 vs 9.8 mL). The N10mm did not differ between AG-PET and PG-PET, irrespective of the motion pattern.

Conclusion: Amplitude gating PET is considered to be more accurate than phase gating PET for examining unstable respiratory motion patterns, such as those involving a variable amplitude or changing baseline.

本文言語英語
ページ(範囲)770-779
ページ数10
ジャーナルAnnals of Nuclear Medicine
28
8
DOI
出版ステータス出版済み - 10 16 2014

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

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