Acquisition of HIV type 1 resistance by β-chemokine-producing CD4+ T cells

Naoyoshi Maeda, Yoshio Koyanagi, Naoko Misawa, Naoko Miyano-Kurosaki, Jun Ichi Kira, Naoki Yamamoto

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)


The CD4+ T cell is a major target cell type for human immunodeficiency virus type 1 (HIV-1) infection, in this study, we provide evidence that the susceptibility to HIV-1 infection is variable in individual CD4+ T cells. Five CD4+ T cell clones were isolated from an HIV-1-seronegative donor and were investigated for their susceptibility to HIV-1 infection. Four CD4+ T cell clones were resistant to infection by a macrophage-tropic (R5) HIV-1 isolate whereas one clone was fully permissive. The level of susceptibility to HIV-1 correlated inversely with β-chemokine production, including RANTES (regulated on activation, normally T cell expressed and secreted), macrophage inflammatory protein 1α (MIP-1α), and MIP-1β. Resistance to HIV-1 infection was abrogated by the combined use of neutralizing antibodies against these three β-chemokines. Interestingly, a complete inhibition of HIV-1 infection was observed in peripheral blood mononuclear cells on infection induced by adding the culture supernatant or a small number of HIV, 1-resistant cell clones. Our results suggest the presence of a clonal self- defense mechanism within the CD4+ T cell population in vivo that involves the secretion of β-chemokines.

ジャーナルAIDS Research and Human Retroviruses
出版ステータス出版済み - 11 1 1999

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology
  • Infectious Diseases

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