Activating HRAS mutation in a case of inverted ductal papilloma of the salivary gland

Fumio Ide, Yumi Ito, Kentaro Kikuchi, Kazuhito Satomura, Ikuko Ogawa, Hidetaka Yamamoto

研究成果: Contribution to journalArticle査読

抄録

Inverted ductal papilloma (IDP) is one of the least common benign papillary/cystic neoplasms of the salivary duct system, being characterized histologically by florid hyperplasia of duct-type epithelial cells into a cystic lumen near the orifice with occasional endophytic growth of the surface squamous epithelium along the terminus of the affected excretory duct. Given its rarity, the exact etiology of IDP remains to be defined. We herein present the first evidence of oncogenic HRAS mutation in a case of oral IDP. This finding, together with the frequent and specific BRAF mutations in sialadenoma papilliferum reported in the recent literature, supports an active role of the MAP-kinase cascade in the pathogenesis of benign papillary neoplasms of terminal duct origin.

本文言語英語
ジャーナルPathology International
DOI
出版ステータス受理済み/印刷中 - 2021
外部発表はい

All Science Journal Classification (ASJC) codes

  • 病理学および法医学

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