Activation and alteration of base selectivity by metal cations in the functionality-transfer reaction for RNA modification

Kazumitsu Onizuka, Yosuke Taniguchi, Shigeki Sasaki

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

Previously, we reported that the 2-methylidene-1,3-diketone unit of 6-thioguanosine transferred selectively to the amino group of cytosine at pH 7.0 and that its selectivity was changed to the guanine base at pH 9.6. In this study, it was found that the functionality-transfer reaction enhanced selectivity for the guanine base in the presence of divalent transition metal cations such as Ni2+ and Co2+ at pH 7.4.

本文言語英語
ページ(範囲)1508-1512
ページ数5
ジャーナルBioconjugate Chemistry
21
8
DOI
出版ステータス出版済み - 8 18 2010

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

フィンガープリント 「Activation and alteration of base selectivity by metal cations in the functionality-transfer reaction for RNA modification」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル