TY - JOUR
T1 - Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis
AU - Hobloss, Samir
AU - Bruguière, Antoine
AU - Pertuit, David
AU - Miyamoto, Tomofumi
AU - Tanaka, Chiaki
AU - Belloir, Christine
AU - Lacaille-Dubois, Marie Aleth
AU - Briand, Loïc
AU - Mitaine-Offer, Anne Claire
N1 - Funding Information:
This research was supported by a grant from the French Government (French Ministry of Higher Education, Research and Innovation).
Publisher Copyright:
© 2022 by the authors.
PY - 2022/11
Y1 - 2022/11
N2 - The phytochemical study of Wisteria sinensis (Sims) DC. (Fabaceae), commonly known as the Chinese Wisteria, led to the isolation of seven oleanane-type glycosides from an aqueous-ethanolic extract of the roots. Among the seven isolated saponins, two have never been reported before: 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranosyl-22-O-acetylolean-12-ene-3β,16β,22β,30-tetrol, and 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucuronopyranosylwistariasapogenol A. Based on the close structures between the saponins from W. sinensis, and the glycyrrhizin from licorice, the stimulation of the sweet taste receptor TAS1R2/TAS1R3 by these glycosides was evaluated.
AB - The phytochemical study of Wisteria sinensis (Sims) DC. (Fabaceae), commonly known as the Chinese Wisteria, led to the isolation of seven oleanane-type glycosides from an aqueous-ethanolic extract of the roots. Among the seven isolated saponins, two have never been reported before: 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranosyl-22-O-acetylolean-12-ene-3β,16β,22β,30-tetrol, and 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucuronopyranosylwistariasapogenol A. Based on the close structures between the saponins from W. sinensis, and the glycyrrhizin from licorice, the stimulation of the sweet taste receptor TAS1R2/TAS1R3 by these glycosides was evaluated.
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U2 - 10.3390/molecules27227866
DO - 10.3390/molecules27227866
M3 - Article
AN - SCOPUS:85142639561
SN - 1420-3049
VL - 27
JO - Molecules
JF - Molecules
IS - 22
M1 - 7866
ER -