Activation of inward current associated with M-potassium current inhibition in m1-muscarinic receptor-transformed NG108-15 cells by KST-5452, a novel cognition enhancer

Hideyuki Kishida, Kozo Yamamoto, Yoshihide Fuse, Mami Noda, Haruhiro Higashida

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

The electrophysiological effects of KST-5452 [3-(m-phenoxybenzylidene)-quinuclidine], an M1 muscarinic acetylcholine receptor (muscarinic AChR) binding compound, were studied in NG108-15 neuroblastoma × glioma hybrid cells transfected with ml muscarinic AChR cDNA. Application of KST-5452 to m1-transformed NGPM1-27 cells elicited a sustained inward current associated with decreased conductance and reduced M-current relaxations at a holding potential of -20 mV. The KST-5452-induced responses were blocked by pirenzepine, suggesting that KST-5452 acts as a potent excitant via M1 muscarinic AChRs in brain neurons.

元の言語英語
ページ(範囲)119-121
ページ数3
ジャーナルNeuroscience Letters
172
発行部数1-2
DOI
出版物ステータス出版済み - 5 19 1994
外部発表Yes

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Muscarinic M1 Receptors
Cognition
Potassium
Muscarinic Receptors
Pirenzepine
Hybrid Cells
Neuroblastoma
Glioma
Cholinergic Agents
Complementary DNA
Inhibition (Psychology)
KST 5452
Neurons
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Activation of inward current associated with M-potassium current inhibition in m1-muscarinic receptor-transformed NG108-15 cells by KST-5452, a novel cognition enhancer. / Kishida, Hideyuki; Yamamoto, Kozo; Fuse, Yoshihide; Noda, Mami; Higashida, Haruhiro.

:: Neuroscience Letters, 巻 172, 番号 1-2, 19.05.1994, p. 119-121.

研究成果: ジャーナルへの寄稿記事

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abstract = "The electrophysiological effects of KST-5452 [3-(m-phenoxybenzylidene)-quinuclidine], an M1 muscarinic acetylcholine receptor (muscarinic AChR) binding compound, were studied in NG108-15 neuroblastoma × glioma hybrid cells transfected with ml muscarinic AChR cDNA. Application of KST-5452 to m1-transformed NGPM1-27 cells elicited a sustained inward current associated with decreased conductance and reduced M-current relaxations at a holding potential of -20 mV. The KST-5452-induced responses were blocked by pirenzepine, suggesting that KST-5452 acts as a potent excitant via M1 muscarinic AChRs in brain neurons.",
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