Active accumulation of gold nanorods in tumor in response to near-infrared laser irradiation

Atsushi Shiotani, Yasuyuki Akiyama, Takahito Kawano, Yasuro Niidome, Takeshi Mori, Yoshiki Katayama, Takuro Niidome

    研究成果: Contribution to journalArticle査読

    40 被引用数 (Scopus)

    抄録

    Gold nanorods, rod-shaped gold nanoparticles, have strong absorbance in the near-infrared region, and the absorbed light energy can be converted to heat, the so-called photothermal effect. The gold nanorods were coated with thermoresponsive polymers, which have different phase transition temperatures that were controlled by adding comonomers, N,N-dimethylacrylamide (DMAA) or acrylamide (AAm) to N-isopropylacrylamide (NIPAM). The phase transition temperatures of poly(NIPAM-DMAA) and poly(NIPAM-AAm)-coated gold nanorods were 38 and 41 °C, respectively, while polyNIPAM-coated gold nanorods showed phase transition at 34 °C. Irradiation of the coated gold nanorods using the near-infrared laser induced a decrease in their sizes due to a phase transition of the polymer layers. Poly(NIPAM-AAm)-coated gold nanorods stably circulated in the blood flow without a phase transition after intravenous injection. Irradiation of near-infrared light at a tumor after the injection resulted in the gold specifically accumulating in the tumor. This novel accumulation technique which combines a thermoresponsive polymer and the photothermal effect of the gold nanorods should be a powerful tool for targeted delivery in response to light irradiation.

    本文言語英語
    ページ(範囲)2049-2054
    ページ数6
    ジャーナルBioconjugate Chemistry
    21
    11
    DOI
    出版ステータス出版済み - 11 17 2010

    All Science Journal Classification (ASJC) codes

    • バイオテクノロジー
    • バイオエンジニアリング
    • 生体医工学
    • 薬理学
    • 薬科学
    • 有機化学

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