Active accumulation of gold nanorods in tumor in response to near-infrared laser irradiation

Atsushi Shiotani, Yasuyuki Akiyama, Takahito Kawano, Yasuro Niidome, Takeshi Mori, Yoshiki Katayama, Takuro Niidome

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

抄録

Gold nanorods, rod-shaped gold nanoparticles, have strong absorbance in the near-infrared region, and the absorbed light energy can be converted to heat, the so-called photothermal effect. The gold nanorods were coated with thermoresponsive polymers, which have different phase transition temperatures that were controlled by adding comonomers, N,N-dimethylacrylamide (DMAA) or acrylamide (AAm) to N-isopropylacrylamide (NIPAM). The phase transition temperatures of poly(NIPAM-DMAA) and poly(NIPAM-AAm)-coated gold nanorods were 38 and 41 °C, respectively, while polyNIPAM-coated gold nanorods showed phase transition at 34 °C. Irradiation of the coated gold nanorods using the near-infrared laser induced a decrease in their sizes due to a phase transition of the polymer layers. Poly(NIPAM-AAm)-coated gold nanorods stably circulated in the blood flow without a phase transition after intravenous injection. Irradiation of near-infrared light at a tumor after the injection resulted in the gold specifically accumulating in the tumor. This novel accumulation technique which combines a thermoresponsive polymer and the photothermal effect of the gold nanorods should be a powerful tool for targeted delivery in response to light irradiation.

元の言語英語
ページ(範囲)2049-2054
ページ数6
ジャーナルBioconjugate Chemistry
21
発行部数11
DOI
出版物ステータス出版済み - 11 17 2010

Fingerprint

Nanotubes
Infrared lasers
Laser beam effects
Nanorods
Gold
Tumors
Lasers
Phase Transition
Phase transitions
Neoplasms
Acrylamide
Polymers
Transition Temperature
Irradiation
Light
Superconducting transition temperature
Infrared radiation
Intravenous Injections
Nanoparticles
Blood

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

これを引用

Active accumulation of gold nanorods in tumor in response to near-infrared laser irradiation. / Shiotani, Atsushi; Akiyama, Yasuyuki; Kawano, Takahito; Niidome, Yasuro; Mori, Takeshi; Katayama, Yoshiki; Niidome, Takuro.

:: Bioconjugate Chemistry, 巻 21, 番号 11, 17.11.2010, p. 2049-2054.

研究成果: ジャーナルへの寄稿記事

Shiotani, Atsushi ; Akiyama, Yasuyuki ; Kawano, Takahito ; Niidome, Yasuro ; Mori, Takeshi ; Katayama, Yoshiki ; Niidome, Takuro. / Active accumulation of gold nanorods in tumor in response to near-infrared laser irradiation. :: Bioconjugate Chemistry. 2010 ; 巻 21, 番号 11. pp. 2049-2054.
@article{2add090951754ea88362f78261a1ff7f,
title = "Active accumulation of gold nanorods in tumor in response to near-infrared laser irradiation",
abstract = "Gold nanorods, rod-shaped gold nanoparticles, have strong absorbance in the near-infrared region, and the absorbed light energy can be converted to heat, the so-called photothermal effect. The gold nanorods were coated with thermoresponsive polymers, which have different phase transition temperatures that were controlled by adding comonomers, N,N-dimethylacrylamide (DMAA) or acrylamide (AAm) to N-isopropylacrylamide (NIPAM). The phase transition temperatures of poly(NIPAM-DMAA) and poly(NIPAM-AAm)-coated gold nanorods were 38 and 41 °C, respectively, while polyNIPAM-coated gold nanorods showed phase transition at 34 °C. Irradiation of the coated gold nanorods using the near-infrared laser induced a decrease in their sizes due to a phase transition of the polymer layers. Poly(NIPAM-AAm)-coated gold nanorods stably circulated in the blood flow without a phase transition after intravenous injection. Irradiation of near-infrared light at a tumor after the injection resulted in the gold specifically accumulating in the tumor. This novel accumulation technique which combines a thermoresponsive polymer and the photothermal effect of the gold nanorods should be a powerful tool for targeted delivery in response to light irradiation.",
author = "Atsushi Shiotani and Yasuyuki Akiyama and Takahito Kawano and Yasuro Niidome and Takeshi Mori and Yoshiki Katayama and Takuro Niidome",
year = "2010",
month = "11",
day = "17",
doi = "10.1021/bc100284s",
language = "English",
volume = "21",
pages = "2049--2054",
journal = "Bioconjugate Chemistry",
issn = "1043-1802",
publisher = "American Chemical Society",
number = "11",

}

TY - JOUR

T1 - Active accumulation of gold nanorods in tumor in response to near-infrared laser irradiation

AU - Shiotani, Atsushi

AU - Akiyama, Yasuyuki

AU - Kawano, Takahito

AU - Niidome, Yasuro

AU - Mori, Takeshi

AU - Katayama, Yoshiki

AU - Niidome, Takuro

PY - 2010/11/17

Y1 - 2010/11/17

N2 - Gold nanorods, rod-shaped gold nanoparticles, have strong absorbance in the near-infrared region, and the absorbed light energy can be converted to heat, the so-called photothermal effect. The gold nanorods were coated with thermoresponsive polymers, which have different phase transition temperatures that were controlled by adding comonomers, N,N-dimethylacrylamide (DMAA) or acrylamide (AAm) to N-isopropylacrylamide (NIPAM). The phase transition temperatures of poly(NIPAM-DMAA) and poly(NIPAM-AAm)-coated gold nanorods were 38 and 41 °C, respectively, while polyNIPAM-coated gold nanorods showed phase transition at 34 °C. Irradiation of the coated gold nanorods using the near-infrared laser induced a decrease in their sizes due to a phase transition of the polymer layers. Poly(NIPAM-AAm)-coated gold nanorods stably circulated in the blood flow without a phase transition after intravenous injection. Irradiation of near-infrared light at a tumor after the injection resulted in the gold specifically accumulating in the tumor. This novel accumulation technique which combines a thermoresponsive polymer and the photothermal effect of the gold nanorods should be a powerful tool for targeted delivery in response to light irradiation.

AB - Gold nanorods, rod-shaped gold nanoparticles, have strong absorbance in the near-infrared region, and the absorbed light energy can be converted to heat, the so-called photothermal effect. The gold nanorods were coated with thermoresponsive polymers, which have different phase transition temperatures that were controlled by adding comonomers, N,N-dimethylacrylamide (DMAA) or acrylamide (AAm) to N-isopropylacrylamide (NIPAM). The phase transition temperatures of poly(NIPAM-DMAA) and poly(NIPAM-AAm)-coated gold nanorods were 38 and 41 °C, respectively, while polyNIPAM-coated gold nanorods showed phase transition at 34 °C. Irradiation of the coated gold nanorods using the near-infrared laser induced a decrease in their sizes due to a phase transition of the polymer layers. Poly(NIPAM-AAm)-coated gold nanorods stably circulated in the blood flow without a phase transition after intravenous injection. Irradiation of near-infrared light at a tumor after the injection resulted in the gold specifically accumulating in the tumor. This novel accumulation technique which combines a thermoresponsive polymer and the photothermal effect of the gold nanorods should be a powerful tool for targeted delivery in response to light irradiation.

UR - http://www.scopus.com/inward/record.url?scp=78649279719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649279719&partnerID=8YFLogxK

U2 - 10.1021/bc100284s

DO - 10.1021/bc100284s

M3 - Article

C2 - 20925427

AN - SCOPUS:78649279719

VL - 21

SP - 2049

EP - 2054

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

SN - 1043-1802

IS - 11

ER -