Activin type IB receptor signaling in prostate cancer cells promotes lymph node metastasis in a xenograft model

Masatoshi Nomura, Kimitaka Tanaka, Lixiang Wang, Yutaka Goto, Chizu Mukasa, Kenji Ashida, Ryoichi Takayanagi

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Activin, a member of the transforming growth factor-β family, has been known to be a growth and differentiating factor. Despite its pluripotent effects, the roles of activin signaling in prostate cancer pathogenesis are still unclear. In this study, we established several cell lines that express a constitutive active form of activin type IB receptor (ActRIBCA) in human prostate cancer cells, ALVA41 (ALVA-ActRIBCA). There was no apparent change in the proliferation of ALVA-ActRIBCA cells in vitro; however, their migratory ability was significantly enhanced. In a xenograft model, histological analysis revealed that the expression of Snail, a cell-adhesion-suppressing transcription factor, was dramatically increased in ALVA-ActRIBCA tumors, indicating epithelial mesenchymal transition (EMT). Finally, mice bearing ALVA-ActRIBCA cells developed multiple lymph node metastases. In this study, we demonstrated that ActRIBCA signaling can promote cell migration in prostate cancer cells via a network of signaling molecules that work together to trigger the process of EMT, and thereby aid in the aggressiveness and progression of prostate cancers.

本文言語英語
ページ(範囲)340-346
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
430
1
DOI
出版ステータス出版済み - 1 4 2013

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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