抄録
The effect of trans fat on the activities of liver mitochondrial and peroxisomal fatty acid oxidation enzymes was examined in various strains of rats. When Wistar and Sprague-Dawley rats were fed for 30 days diets containing either olive oil or partially hydrogenated corn oil as a source of cis-or trans-octadecenoate, respectively, the activities of various enzymes of mitochondrial and peroxisomal β-oxidation measured with cis- and trans-9-octadecenoic acid as substratese showed little dietary fatdependent change. In Fischer 344 rats, feeding trans fat for 15 mo increased only moderately various enzymes of β-oxidation except for carnitine acyltransferase. The rate of mitochondrial ketogenesis and the activity of carnitine acyltransferase measured with trans-9-octadecenoic acid as a substrate were about half those with the cis-counterpart. Peroxisomes oxidized trans-9-octadecenoyl-CoA at a rate comparable to the cis-counterpart. It was concluded from this study and previous ones that the difference in the geometry of dietary fatty acid had only a marginal effect in modulating the hepatic fatty acid oxidation system, in spite of marked differences in the metabolic behavior of cis-and trans fatty acid in cell-free preparations and perfused liver.
本文言語 | 英語 |
---|---|
ページ(範囲) | 6-10 |
ページ数 | 5 |
ジャーナル | Lipids |
巻 | 22 |
号 | 1 |
DOI | |
出版ステータス | 出版済み - 1月 1 1987 |
!!!All Science Journal Classification (ASJC) codes
- 生化学
- 有機化学
- 細胞生物学