Activities of liver mitochondrial and peroxisomal fatty acid oxidation enzymes in rats fed trans fat

Takashi Ide, Midori Watanabe, Michihiro Sugano, Iwahiko Yamamoto

研究成果: ジャーナルへの寄稿記事

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The effect of trans fat on the activities of liver mitochondrial and peroxisomal fatty acid oxidation enzymes was examined in various strains of rats. When Wistar and Sprague-Dawley rats were fed for 30 days diets containing either olive oil or partially hydrogenated corn oil as a source of cis-or trans-octadecenoate, respectively, the activities of various enzymes of mitochondrial and peroxisomal β-oxidation measured with cis- and trans-9-octadecenoic acid as substratese showed little dietary fatdependent change. In Fischer 344 rats, feeding trans fat for 15 mo increased only moderately various enzymes of β-oxidation except for carnitine acyltransferase. The rate of mitochondrial ketogenesis and the activity of carnitine acyltransferase measured with trans-9-octadecenoic acid as a substrate were about half those with the cis-counterpart. Peroxisomes oxidized trans-9-octadecenoyl-CoA at a rate comparable to the cis-counterpart. It was concluded from this study and previous ones that the difference in the geometry of dietary fatty acid had only a marginal effect in modulating the hepatic fatty acid oxidation system, in spite of marked differences in the metabolic behavior of cis-and trans fatty acid in cell-free preparations and perfused liver.

元の言語英語
ページ(範囲)6-10
ページ数5
ジャーナルLipids
22
発行部数1
DOI
出版物ステータス出版済み - 1 1 1987

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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