Acute heat stress up-regulates neuropeptide Y precursor mRNA expression and alters brain and plasma concentrations of free amino acids in chicks

Kentaro Ito, Mohammad A. Bahry, Yang Hui, Mitsuhiro Furuse, Vishwajit Surchowdhury

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

抄録

Heat stress causes an increase in body temperature and reduced food intake in chickens. Several neuropeptides and amino acids play a vital role in the regulation of food intake. However, the responses of neuropeptides and amino acids to heat-stress-induced food-intake regulation are poorly understood. In the current study, the hypothalamic mRNA expression of some neuropeptides related to food intake and the content of free amino acids in the brain and plasma was examined in 14-day-old chicks exposed to a high ambient temperature (HT; 40 ± 1. °C for 2 or 5 h) or to a control thermoneutral temperature (CT; 30 ± 1 °C). HT significantly increased rectal temperature and plasma corticosterone level and suppressed food intake. HT also increased the expression of neuropeptide Y (NPY) and agouti-signaling protein (ASIP) precursor mRNA, while no change was observed in pro-opiomelanocortin, cholecystokinin, ghrelin, or corticotropin-releasing hormone precursor mRNA. It was further found that the diencephalic content of free amino acids - namely, tryptophan, leucine, isoleucine, valine and serine - was significantly higher in HT chicks with some alterations in their plasma amino acids in comparison with CT chicks. The induction of NPY and ASIP expression and the alteration of some free amino acids during HT suggest that these changes can be the results or causes the suppression of food intake.

元の言語英語
ページ(範囲)13-19
ページ数7
ジャーナルComparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
187
DOI
出版物ステータス出版済み - 9 1 2015

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Neuropeptide Y
RNA Precursors
Brain
Up-Regulation
Hot Temperature
Plasmas
Amino Acids
Agouti Signaling Protein
Eating
Neuropeptides
Appetite Regulation
tryptophan-leucine
Temperature
Pro-Opiomelanocortin
Messenger RNA
Ghrelin
Protein Precursors
Isoleucine
Corticotropin-Releasing Hormone
Cholecystokinin

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology

これを引用

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abstract = "Heat stress causes an increase in body temperature and reduced food intake in chickens. Several neuropeptides and amino acids play a vital role in the regulation of food intake. However, the responses of neuropeptides and amino acids to heat-stress-induced food-intake regulation are poorly understood. In the current study, the hypothalamic mRNA expression of some neuropeptides related to food intake and the content of free amino acids in the brain and plasma was examined in 14-day-old chicks exposed to a high ambient temperature (HT; 40 ± 1. °C for 2 or 5 h) or to a control thermoneutral temperature (CT; 30 ± 1 °C). HT significantly increased rectal temperature and plasma corticosterone level and suppressed food intake. HT also increased the expression of neuropeptide Y (NPY) and agouti-signaling protein (ASIP) precursor mRNA, while no change was observed in pro-opiomelanocortin, cholecystokinin, ghrelin, or corticotropin-releasing hormone precursor mRNA. It was further found that the diencephalic content of free amino acids - namely, tryptophan, leucine, isoleucine, valine and serine - was significantly higher in HT chicks with some alterations in their plasma amino acids in comparison with CT chicks. The induction of NPY and ASIP expression and the alteration of some free amino acids during HT suggest that these changes can be the results or causes the suppression of food intake.",
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AU - Bahry, Mohammad A.

AU - Hui, Yang

AU - Furuse, Mitsuhiro

AU - Surchowdhury, Vishwajit

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