Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids

Takashi Baba, Hiroyuki Otake, Miki Inoue, Tetsuya Sato, Yasuhiro Ishihara, Ju Yeon Moon, Megumi Tsuchiya, Kanako Miyabayashi, Hidesato Ogawa, Yuichi Shima, Lixiang Wang, Ryuichiro Sato, Takeshi Yamazaki, Mikita Suyama, Masatoshi Nomura, Man Ho Choi, Yasuyuki Ohkawa, Ken ichirou Morohashi

研究成果: ジャーナルへの寄稿記事

抄録

Housekeeping metabolic pathways such as glycolysis are active in all cell types. In addition, many types of cells are equipped with cell-specific metabolic pathways. To properly perform their functions, housekeeping and cell-specific metabolic pathways must function cooperatively. However, the regulatory mechanisms that couple metabolic pathways remain largely unknown. Recently, we showed that the steroidogenic cell-specific nuclear receptor Ad4BP/SF-1, which regulates steroidogenic genes, also regulates housekeeping glycolytic genes. Here, we identify cholesterogenic genes as the targets of Ad4BP/SF-1. Further, we reveal that Ad4BP/SF-1 regulates Hummr, a candidate mediator of cholesterol transport from endoplasmic reticula to mitochondria. Given that cholesterol is the starting material for steroidogenesis and is synthesized from acetyl-CoA, which partly originates from glucose, our results suggest that multiple biological processes involved in synthesizing steroid hormones are governed by Ad4BP/SF-1. To our knowledge, this study provides the first example where housekeeping and cell-specific metabolism are coordinated at the transcriptional level.

元の言語英語
記事番号18
ジャーナルCommunications Biology
1
発行部数1
DOI
出版物ステータス出版済み - 12 1 2018

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steroids
Steroids
Cholesterol
cholesterol
Metabolic Networks and Pathways
Housekeeping
synthesis
biochemical pathways
Genes
Steroid hormones
cells
Acetyl Coenzyme A
Mitochondria
Cytoplasmic and Nuclear Receptors
Metabolism
Biological Phenomena
steroidogenesis
genes
Essential Genes
steroid hormones

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Medicine (miscellaneous)

これを引用

Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids. / Baba, Takashi; Otake, Hiroyuki; Inoue, Miki; Sato, Tetsuya; Ishihara, Yasuhiro; Moon, Ju Yeon; Tsuchiya, Megumi; Miyabayashi, Kanako; Ogawa, Hidesato; Shima, Yuichi; Wang, Lixiang; Sato, Ryuichiro; Yamazaki, Takeshi; Suyama, Mikita; Nomura, Masatoshi; Choi, Man Ho; Ohkawa, Yasuyuki; Morohashi, Ken ichirou.

:: Communications Biology, 巻 1, 番号 1, 18, 01.12.2018.

研究成果: ジャーナルへの寄稿記事

Baba, T, Otake, H, Inoue, M, Sato, T, Ishihara, Y, Moon, JY, Tsuchiya, M, Miyabayashi, K, Ogawa, H, Shima, Y, Wang, L, Sato, R, Yamazaki, T, Suyama, M, Nomura, M, Choi, MH, Ohkawa, Y & Morohashi, KI 2018, 'Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids', Communications Biology, 巻. 1, 番号 1, 18. https://doi.org/10.1038/s42003-018-0020-z
Baba, Takashi ; Otake, Hiroyuki ; Inoue, Miki ; Sato, Tetsuya ; Ishihara, Yasuhiro ; Moon, Ju Yeon ; Tsuchiya, Megumi ; Miyabayashi, Kanako ; Ogawa, Hidesato ; Shima, Yuichi ; Wang, Lixiang ; Sato, Ryuichiro ; Yamazaki, Takeshi ; Suyama, Mikita ; Nomura, Masatoshi ; Choi, Man Ho ; Ohkawa, Yasuyuki ; Morohashi, Ken ichirou. / Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids. :: Communications Biology. 2018 ; 巻 1, 番号 1.
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abstract = "Housekeeping metabolic pathways such as glycolysis are active in all cell types. In addition, many types of cells are equipped with cell-specific metabolic pathways. To properly perform their functions, housekeeping and cell-specific metabolic pathways must function cooperatively. However, the regulatory mechanisms that couple metabolic pathways remain largely unknown. Recently, we showed that the steroidogenic cell-specific nuclear receptor Ad4BP/SF-1, which regulates steroidogenic genes, also regulates housekeeping glycolytic genes. Here, we identify cholesterogenic genes as the targets of Ad4BP/SF-1. Further, we reveal that Ad4BP/SF-1 regulates Hummr, a candidate mediator of cholesterol transport from endoplasmic reticula to mitochondria. Given that cholesterol is the starting material for steroidogenesis and is synthesized from acetyl-CoA, which partly originates from glucose, our results suggest that multiple biological processes involved in synthesizing steroid hormones are governed by Ad4BP/SF-1. To our knowledge, this study provides the first example where housekeeping and cell-specific metabolism are coordinated at the transcriptional level.",
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AU - Otake, Hiroyuki

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AU - Ishihara, Yasuhiro

AU - Moon, Ju Yeon

AU - Tsuchiya, Megumi

AU - Miyabayashi, Kanako

AU - Ogawa, Hidesato

AU - Shima, Yuichi

AU - Wang, Lixiang

AU - Sato, Ryuichiro

AU - Yamazaki, Takeshi

AU - Suyama, Mikita

AU - Nomura, Masatoshi

AU - Choi, Man Ho

AU - Ohkawa, Yasuyuki

AU - Morohashi, Ken ichirou

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