TY - JOUR
T1 - ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children
AU - Matsusue, Aya
AU - Kiyohara, Chikako
AU - Tanaka, Keiko
AU - Sasaki, Satoshi
AU - Miyake, Yoshihiro
N1 - Funding Information:
This study was supported by Health and Labour Sciences Research Grants, Research on Allergic Disease and Immunology from the Ministry of Health, Labour, and Welfare, Japan. The authors would like to acknowledge Ms. Tomoko Tokuyasu for technical assistance.
PY - 2009/4
Y1 - 2009/4
N2 - Objectives: ADAM33, a disintegrin and metalloproteinase 33, gene has been identified as an asthma susceptibility gene. The relationship between single nucleotide polymorphisms (SNPs) in ADAM33 and atopic dermatitis (AD) in Japanese children was examined using case-control design. Methods: Seven SNPs of ADAM33 (rs2853209, rs2787094, rs2280091, rs2280090, rs628977, rs597980, and rs528557) were analyzed in 140 AD cases and 258 controls aged 3 years. Results: Only rs2853209 (T > A) was significantly associated with AD risk. Sex-adjusted odds ratio (OR) for the AA versus the TT genotype was 0.55 (95% confidence interval (CI), 0.30-0.997). Consistent with the results of genotyping analysis, a haplotype carrying rs2853209 A allele was significantly associated with decreased risk of AD compared to all the other haplotypes combined (OR = 0.26, 95% CI = 0.08-0.69). Conclusion: This is the first study to provide evidence for an association of the ADAM33 polymorphism with AD risk but the strength of this evidence is limited by our small sample size.
AB - Objectives: ADAM33, a disintegrin and metalloproteinase 33, gene has been identified as an asthma susceptibility gene. The relationship between single nucleotide polymorphisms (SNPs) in ADAM33 and atopic dermatitis (AD) in Japanese children was examined using case-control design. Methods: Seven SNPs of ADAM33 (rs2853209, rs2787094, rs2280091, rs2280090, rs628977, rs597980, and rs528557) were analyzed in 140 AD cases and 258 controls aged 3 years. Results: Only rs2853209 (T > A) was significantly associated with AD risk. Sex-adjusted odds ratio (OR) for the AA versus the TT genotype was 0.55 (95% confidence interval (CI), 0.30-0.997). Consistent with the results of genotyping analysis, a haplotype carrying rs2853209 A allele was significantly associated with decreased risk of AD compared to all the other haplotypes combined (OR = 0.26, 95% CI = 0.08-0.69). Conclusion: This is the first study to provide evidence for an association of the ADAM33 polymorphism with AD risk but the strength of this evidence is limited by our small sample size.
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U2 - 10.1016/j.clinbiochem.2008.12.014
DO - 10.1016/j.clinbiochem.2008.12.014
M3 - Article
C2 - 19146844
AN - SCOPUS:61849183054
SN - 0009-9120
VL - 42
SP - 477
EP - 483
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 6
ER -