Adenovirus-mediated gene transfer into the brain stem to examine cardiovascular function: Role of nitric oxide and Rho-kinase

Yoshitaka Hirooka

    研究成果: Contribution to journalReview article査読

    8 被引用数 (Scopus)

    抄録

    The central nervous system plays an important role in the regulation of blood pressure via the sympathetic nervous system. Abnormal regulation of the sympathetic nerve activity is involved in the pathophysiology of hypertension. In particular, the brain stem, including the nucleus tractus solitarii (NTS) and the rostral ventrolateral medulla (RVLM), is a key site that controls and maintains blood pressure via the sympathetic nervous system. Nitric oxide (NO) is a unique molecule that influences sympathetic nerve activity. Rho-kinase is a downstream effector of the small GTPase, Rho, and is implicated in various cellular functions. We developed a technique to transfer adenovirus vectors encoding endothelial nitric oxide synthase and dominant-negative Rho-kinase into the NTS or the RVLM of rats in vivo. We applied this technique to hypertensive rats to explore the physiological significance of NO and Rho-kinase.

    本文言語英語
    ページ(範囲)233-249
    ページ数17
    ジャーナルProgress in Biophysics and Molecular Biology
    84
    2-3
    DOI
    出版ステータス出版済み - 2004

    All Science Journal Classification (ASJC) codes

    • 生物理学
    • 分子生物学

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