Adipokines: Therapeutic targets for metabolic syndrome

Kunihisa Kobayashi, Toyoshi Inoguchi

    研究成果: Contribution to journalReview article査読

    60 被引用数 (Scopus)

    抄録

    For a long time it has been known that obesity (adiposity) is linked to insulin resistance. Recently, many investigators have reported that adipocytes secrete a variety of bioactive molecules, termed adipokines (adipocytokines), including TNFα, IL-6, leptin, adiponectin, resistin and so on. These adipokines play pivotal roles in energy homeostasis by affecting insulin sensitivity, glucose and lipid metabolisms, food intake, the coagulation system and inflammation. This review provides a summary of these adipose tissue-secreting biomolecules and discusses their feasibilities as drug targets for the treatment of metabolic syndrome.

    本文言語英語
    ページ(範囲)525-529
    ページ数5
    ジャーナルCurrent Drug Targets
    6
    4
    DOI
    出版ステータス出版済み - 6 2005

    All Science Journal Classification (ASJC) codes

    • 分子医療
    • 薬理学
    • 創薬
    • 臨床生化学

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