TY - JOUR
T1 - Adipokines
T2 - Therapeutic targets for metabolic syndrome
AU - Kobayashi, Kunihisa
AU - Inoguchi, Toyoshi
PY - 2005/6
Y1 - 2005/6
N2 - For a long time it has been known that obesity (adiposity) is linked to insulin resistance. Recently, many investigators have reported that adipocytes secrete a variety of bioactive molecules, termed adipokines (adipocytokines), including TNFα, IL-6, leptin, adiponectin, resistin and so on. These adipokines play pivotal roles in energy homeostasis by affecting insulin sensitivity, glucose and lipid metabolisms, food intake, the coagulation system and inflammation. This review provides a summary of these adipose tissue-secreting biomolecules and discusses their feasibilities as drug targets for the treatment of metabolic syndrome.
AB - For a long time it has been known that obesity (adiposity) is linked to insulin resistance. Recently, many investigators have reported that adipocytes secrete a variety of bioactive molecules, termed adipokines (adipocytokines), including TNFα, IL-6, leptin, adiponectin, resistin and so on. These adipokines play pivotal roles in energy homeostasis by affecting insulin sensitivity, glucose and lipid metabolisms, food intake, the coagulation system and inflammation. This review provides a summary of these adipose tissue-secreting biomolecules and discusses their feasibilities as drug targets for the treatment of metabolic syndrome.
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U2 - 10.2174/1389450054021972
DO - 10.2174/1389450054021972
M3 - Review article
C2 - 16026271
AN - SCOPUS:21444441702
VL - 6
SP - 525
EP - 529
JO - Current Drug Targets
JF - Current Drug Targets
SN - 1389-4501
IS - 4
ER -
