Adiponectin and macrophage

Sumio Akifusa, Yoshihisa Yamashita

研究成果: 著書/レポートタイプへの貢献

抄録

Adipose tissue secretes various bioactive soluble mediator called adipokines. In excess adipose tissue, increase of total amount of proinflammatory adipokines, such as TNF-α and IL-6 are observed, indicating that obesity is associated with a state of low-grade, chronic inflammation. Adiponectin, however, mature adipocyte-derived peptide, shows negative correlation with body mass index and decreases its plasma level in obese. As clinical feature, hypoadiponectinaemia is closely related with onset of metabolic syndrome, cardiovascular disease, and type II diabetes. Administration of adiponectin improves insulin resistance and/or inflammatory condition in vivo. Thus, adiponectin possessing anti-inflammatory and anti-metabolic dysfunctional characterization is expected to be used for treatment and/or preventative agent. In this review, we summarized the role of adiponectin on metabolic and immune function, in particular function of macrophage.

元の言語英語
ホスト出版物のタイトルAdiponectin: Production, Regulation and Roles in Disease
出版者Nova Science Publishers, Inc.
ページ38-47
ページ数10
ISBN(印刷物)9781619421653
出版物ステータス出版済み - 2012

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Adiponectin
Macrophages
Adipokines
Adipose Tissue
Adipocytes
Type 2 Diabetes Mellitus
Insulin Resistance
Interleukin-6
Body Mass Index
Anti-Inflammatory Agents
Cardiovascular Diseases
Obesity
Inflammation
Peptides
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Akifusa, S., & Yamashita, Y. (2012). Adiponectin and macrophage. : Adiponectin: Production, Regulation and Roles in Disease (pp. 38-47). Nova Science Publishers, Inc..

Adiponectin and macrophage. / Akifusa, Sumio; Yamashita, Yoshihisa.

Adiponectin: Production, Regulation and Roles in Disease. Nova Science Publishers, Inc., 2012. p. 38-47.

研究成果: 著書/レポートタイプへの貢献

Akifusa, S & Yamashita, Y 2012, Adiponectin and macrophage. : Adiponectin: Production, Regulation and Roles in Disease. Nova Science Publishers, Inc., pp. 38-47.
Akifusa S, Yamashita Y. Adiponectin and macrophage. : Adiponectin: Production, Regulation and Roles in Disease. Nova Science Publishers, Inc. 2012. p. 38-47
Akifusa, Sumio ; Yamashita, Yoshihisa. / Adiponectin and macrophage. Adiponectin: Production, Regulation and Roles in Disease. Nova Science Publishers, Inc., 2012. pp. 38-47
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