Adiponectin and macrophage

Sumio Akifusa, Yoshihisa Yamashita

研究成果: Chapter in Book/Report/Conference proceedingChapter

抄録

Adipose tissue secretes various bioactive soluble mediator called adipokines. In excess adipose tissue, increase of total amount of proinflammatory adipokines, such as TNF-α and IL-6 are observed, indicating that obesity is associated with a state of low-grade, chronic inflammation. Adiponectin, however, mature adipocyte-derived peptide, shows negative correlation with body mass index and decreases its plasma level in obese. As clinical feature, hypoadiponectinaemia is closely related with onset of metabolic syndrome, cardiovascular disease, and type II diabetes. Administration of adiponectin improves insulin resistance and/or inflammatory condition in vivo. Thus, adiponectin possessing anti-inflammatory and anti-metabolic dysfunctional characterization is expected to be used for treatment and/or preventative agent. In this review, we summarized the role of adiponectin on metabolic and immune function, in particular function of macrophage.

本文言語英語
ホスト出版物のタイトルAdiponectin: Production, Regulation and Roles in Disease
出版社Nova Science Publishers, Inc.
ページ38-47
ページ数10
ISBN(印刷版)9781619421653
出版ステータス出版済み - 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

フィンガープリント 「Adiponectin and macrophage」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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