Adiponectin inhibits Toll-like receptor family-induced signaling

Noboru Yamaguchi, Jose Guillermo Martinez Argueta, Yoshikazu Masuhiro, Maki Kagishita, Kazuaki Nonaka, Toshiyuki Saito, Shigemasa Hanazawa, Yoshihisa Yamashita

研究成果: ジャーナルへの寄稿記事

192 引用 (Scopus)

抄録

Recent studies have shown that adiponectin, an adipocyte-derived cytokine, acts as a potent inhibitor of inflammatory responses. It has been also demonstrated that bacterial and viral signalings in host cells are triggered via Toll-like receptor (TLR) molecules. Therefore, in the present study, we investigated whether globular adiponectin (gAd) would be able to inhibit TLR-mediated nuclear factor-κB (NF-κB) signaling in mouse macrophages (RAW264). gAd predominantly bound to the AdipoR1 receptor and suppressed TLR-mediated NF-κB signaling. gAd-mediated inhibition of TLR-mediated IκB phosphorylation and NF-κB activation was eliminated by the pretreatment of cycloheximide. Also their inhibitions of gAd were blocked by preincubation of the cells with an antibody against AdipoR1, but not with an antibody against AdipoR2. Taken together, these findings indicate that adiponectin negatively regulates macrophage-like cell response to TLR ligands via an unknown endogenous product(s).

元の言語英語
ページ(範囲)6821-6826
ページ数6
ジャーナルFEBS Letters
579
発行部数30
DOI
出版物ステータス出版済み - 12 19 2005

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Toll-Like Receptors
Adiponectin
Macrophages
Phosphorylation
Antibodies
Cycloheximide
Adipocytes
Chemical activation
Cytokines
Ligands
Molecules

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

これを引用

Yamaguchi, N., Argueta, J. G. M., Masuhiro, Y., Kagishita, M., Nonaka, K., Saito, T., ... Yamashita, Y. (2005). Adiponectin inhibits Toll-like receptor family-induced signaling. FEBS Letters, 579(30), 6821-6826. https://doi.org/10.1016/j.febslet.2005.11.019

Adiponectin inhibits Toll-like receptor family-induced signaling. / Yamaguchi, Noboru; Argueta, Jose Guillermo Martinez; Masuhiro, Yoshikazu; Kagishita, Maki; Nonaka, Kazuaki; Saito, Toshiyuki; Hanazawa, Shigemasa; Yamashita, Yoshihisa.

:: FEBS Letters, 巻 579, 番号 30, 19.12.2005, p. 6821-6826.

研究成果: ジャーナルへの寄稿記事

Yamaguchi, N, Argueta, JGM, Masuhiro, Y, Kagishita, M, Nonaka, K, Saito, T, Hanazawa, S & Yamashita, Y 2005, 'Adiponectin inhibits Toll-like receptor family-induced signaling', FEBS Letters, 巻. 579, 番号 30, pp. 6821-6826. https://doi.org/10.1016/j.febslet.2005.11.019
Yamaguchi N, Argueta JGM, Masuhiro Y, Kagishita M, Nonaka K, Saito T その他. Adiponectin inhibits Toll-like receptor family-induced signaling. FEBS Letters. 2005 12 19;579(30):6821-6826. https://doi.org/10.1016/j.febslet.2005.11.019
Yamaguchi, Noboru ; Argueta, Jose Guillermo Martinez ; Masuhiro, Yoshikazu ; Kagishita, Maki ; Nonaka, Kazuaki ; Saito, Toshiyuki ; Hanazawa, Shigemasa ; Yamashita, Yoshihisa. / Adiponectin inhibits Toll-like receptor family-induced signaling. :: FEBS Letters. 2005 ; 巻 579, 番号 30. pp. 6821-6826.
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