Administering xCT inhibitors based on circadian clock improves antitumor effects

Fumiyasu Okazaki, Naoya Matsunaga, Kengo Hamamura, Kayoko Suzuki, Takaharu Nakao, Hiroyuki Okazaki, Masahiko Kutsukake, Shiro Fukumori, Yasuhiro Tsuji, Hideto To

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

Clock genes encoding transcription factors that regulate circadian rhythms may inform chronomodulated chemotherapy, where time-dependent dose alterations might affect drug efficacy and reduce side effects. For example, inhibiting the essential cystine transporter xCT with sulfasalazine induces growth arrest in cancer cells. Although the anticancer effects of sulfasalazine have been studied extensively, its effects on transcriptional control of xCT expression have not been studied. Here, we show that sulfasalazine administration during the period of increased xCT expression improves its anticancer effects and that the Clock gene itself induces xCT expression and regulates its circadian rhythm. Our findings highlight the clinical potential of chronomodulated chemotherapy and the importance of xCT-mediated transcriptional regulation in the utility of such strategies.

本文言語英語
ページ(範囲)6603-6613
ページ数11
ジャーナルCancer Research
77
23
DOI
出版ステータス出版済み - 12 1 2017

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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