Le développement du cortex surrénalien: leçons des modèles animaux

Typhanie Dumontet, Isabelle Sahut-Barnola, Amandine Septier, Nathanaëlle Montanier, Ingrid Plotton, Florence Roucher-Boulez, Véronique Ducros, Anne Marie Lefrançois-Martinez, Jean Christophe Pointud, Mohamad Zubair, Ken-Ichirou Morohashi, David T. Breault, Pierre Val, Antoine Martinez

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

The adrenocortical gland undergoes structural and functional remodelling in the fetal and postnatal periods. After birth, the fetal zone of the gland undergoes rapid involution in favor of the definitive cortex, which reaches maturity with the emergence of the zona reticularis(zR) at the adrenarche. The mechanisms underlying the adrenarche, the process leading to pre-puberty elevation of plasma androgens in higher primates, remain unknown, largely due to lack of any experimental model. By following up fetal and definitive cortex cell lines in mice, we showed that activation of protein kinase A (PKA) signaling mainly impacts the adult cortex by stimulating centripetal regeneration, with differentiation and then conversion of the zona fasciculata into a functional zR. Animals developed Cushing syndrome associated with primary hyperaldosteronism, suggesting possible coexistence of these hypersecretions in certain patients. Remarkably, all of these traits were sex-dependent: testicular androgens promoted WNT signaling antagonism on PKA, slowing cortical renewal and delaying onset of Cushing syndrome and the establishment of the zR in male mice, this being corrected by orchidectomy. In conclusion, zR derives from centripetal conversion of the zona fasciculata under cellular renewal induced by PKA signaling, determining the size of the adult cortex. Finally, we demonstrated that this PKA-dependent mobilization of cortical progenitors is sexually dimorphic and could, if confirmed in humans, account for female preponderance in adrenocortical pathologies.

元の言語フランス語
ページ(範囲)95-97
ページ数3
ジャーナルAnnales d'Endocrinologie
79
発行部数3
DOI
出版物ステータス出版済み - 6 1 2018

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Zona Reticularis
Cyclic AMP-Dependent Protein Kinases
Adrenarche
Zona Fasciculata
Cushing Syndrome
Androgens
Hyperaldosteronism
Orchiectomy
Puberty
Primates
Regeneration
Theoretical Models
Parturition
Pathology
Cell Line

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

Dumontet, T., Sahut-Barnola, I., Septier, A., Montanier, N., Plotton, I., Roucher-Boulez, F., ... Martinez, A. (2018). Le développement du cortex surrénalien: leçons des modèles animaux. Annales d'Endocrinologie, 79(3), 95-97. https://doi.org/10.1016/j.ando.2018.03.014

Le développement du cortex surrénalien : leçons des modèles animaux. / Dumontet, Typhanie; Sahut-Barnola, Isabelle; Septier, Amandine; Montanier, Nathanaëlle; Plotton, Ingrid; Roucher-Boulez, Florence; Ducros, Véronique; Lefrançois-Martinez, Anne Marie; Pointud, Jean Christophe; Zubair, Mohamad; Morohashi, Ken-Ichirou; Breault, David T.; Val, Pierre; Martinez, Antoine.

:: Annales d'Endocrinologie, 巻 79, 番号 3, 01.06.2018, p. 95-97.

研究成果: ジャーナルへの寄稿記事

Dumontet, T, Sahut-Barnola, I, Septier, A, Montanier, N, Plotton, I, Roucher-Boulez, F, Ducros, V, Lefrançois-Martinez, AM, Pointud, JC, Zubair, M, Morohashi, K-I, Breault, DT, Val, P & Martinez, A 2018, 'Le développement du cortex surrénalien: leçons des modèles animaux', Annales d'Endocrinologie, 巻. 79, 番号 3, pp. 95-97. https://doi.org/10.1016/j.ando.2018.03.014
Dumontet T, Sahut-Barnola I, Septier A, Montanier N, Plotton I, Roucher-Boulez F その他. Le développement du cortex surrénalien: leçons des modèles animaux. Annales d'Endocrinologie. 2018 6 1;79(3):95-97. https://doi.org/10.1016/j.ando.2018.03.014
Dumontet, Typhanie ; Sahut-Barnola, Isabelle ; Septier, Amandine ; Montanier, Nathanaëlle ; Plotton, Ingrid ; Roucher-Boulez, Florence ; Ducros, Véronique ; Lefrançois-Martinez, Anne Marie ; Pointud, Jean Christophe ; Zubair, Mohamad ; Morohashi, Ken-Ichirou ; Breault, David T. ; Val, Pierre ; Martinez, Antoine. / Le développement du cortex surrénalien : leçons des modèles animaux. :: Annales d'Endocrinologie. 2018 ; 巻 79, 番号 3. pp. 95-97.
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AU - Montanier, Nathanaëlle

AU - Plotton, Ingrid

AU - Roucher-Boulez, Florence

AU - Ducros, Véronique

AU - Lefrançois-Martinez, Anne Marie

AU - Pointud, Jean Christophe

AU - Zubair, Mohamad

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