Adrenocorticotropin receptor in familial glucocorticoid deficiency

R. Takayanagi, Y. Sakai, H. Nawata, S. Nishiyama, T. Ito, M. Kodama, I. Matsuda, H. Matsuda

研究成果: Contribution to journalReview article

4 引用 (Scopus)

抜粋

Recent studies have revealed the presence of four subtypes for the melanocortin receptor (MC-R). Among these MC-Rs, MC2-R is considered to be an adrenocorticotropin (ACTH) receptor because its expression is almost localized in the adrenal cortex. Five Japanese patients with ACTH unresponsiveness were examined as to whether they have mutations in the putative ACTH receptor. Among these patients, there are two groups of siblings, each of which consists of two individuals. The coding region of the ACTH receptor gene was amplified by polymerase chain reaction and directly sequenced on both strands, however, no point mutation was found in any of the five patients, suggesting that familial glucocorticoid deficiency, caused by the mutated ACTH receptor, may be rare.

元の言語英語
ページ(範囲)2643-2648
ページ数6
ジャーナルNippon rinsho. Japanese journal of clinical medicine
51
発行部数10
出版物ステータス出版済み - 10 1993

All Science Journal Classification (ASJC) codes

  • Medicine(all)

フィンガープリント Adrenocorticotropin receptor in familial glucocorticoid deficiency' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Takayanagi, R., Sakai, Y., Nawata, H., Nishiyama, S., Ito, T., Kodama, M., Matsuda, I., & Matsuda, H. (1993). Adrenocorticotropin receptor in familial glucocorticoid deficiency. Nippon rinsho. Japanese journal of clinical medicine, 51(10), 2643-2648.