Adult rhabdomyosarcoma in the nasal and paranasal sinuses showing complete local response to a combination of chemotherapy and radiotherapy using 3D-CRT and IMRT.

Emi Muto, Yoshiyuki Shioyama, Katsumasa Nakamura, Ohga Saiji, Satoshi Nomoto, Takashi Toba, Tadamasa Yoshitake, Hiroyasu Soeda, Hiromi Terashima, Hiroshi Honda

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

We report on a 69-year-old woman with rhabdomyosarcoma arising from the nasal and paranasal sinuses. She was referred to our hospital with a reduced ability to smell and impaired bilateral vision, narrowing of the visual field, and left facial pain. Computed tomography (CT) revealed a large tumor in the nasal and left paranasal sinuses invading the left orbital cavity and anterior skull base, and lymph node swellings in the submental and left accessory nerve areas. A biopsy specimen from the nasal tumor was diagnosed histologically as a rhabdomyosarcoma, alveolar type. Because the intracranial direct invasion and distant metastases to the thoracic spine were suspected by pretreatment examination, our case was determined to be inoperable by a head and neck surgeon. Radiotherapy with a total dose of 60 Gy was carried out to control the primary disease. The three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) techniques were used in order to reduce the doses to risk organs. Combined with radiotherapy, chemotherapy was also performed for the treatment of lymph-node metastases and distant diseases. After the treatment was completed, the primary tumor and lymph-node metastases disappeared completely; there was no sign of re-growth during the follow-up period. Chemoradiotherapy may be an effective treatment also for inoperable adult rhabdomyosarcoma in the head and neck region. Furthermore, the 3D-CRT and IMRT techniques are both useful methods of radiotherapy for this disease.

元の言語英語
ページ(範囲)363-369
ページ数7
ジャーナルFukuoka igaku zasshi = Hukuoka acta medica
96
発行部数10
出版物ステータス出版済み - 1 1 2005

Fingerprint

Intensity-Modulated Radiotherapy
Rhabdomyosarcoma
Paranasal Sinuses
Combination Drug Therapy
Radiotherapy
Lymph Nodes
Neoplasm Metastasis
Nose
Neck
Head
Alveolar Rhabdomyosarcoma
Accessory Nerve
Conformal Radiotherapy
Neoplasms
Facial Pain
Aptitude
Smell
Skull Base
Chemoradiotherapy
Visual Fields

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Adult rhabdomyosarcoma in the nasal and paranasal sinuses showing complete local response to a combination of chemotherapy and radiotherapy using 3D-CRT and IMRT. / Muto, Emi; Shioyama, Yoshiyuki; Nakamura, Katsumasa; Saiji, Ohga; Nomoto, Satoshi; Toba, Takashi; Yoshitake, Tadamasa; Soeda, Hiroyasu; Terashima, Hiromi; Honda, Hiroshi.

:: Fukuoka igaku zasshi = Hukuoka acta medica, 巻 96, 番号 10, 01.01.2005, p. 363-369.

研究成果: ジャーナルへの寄稿記事

Muto, Emi ; Shioyama, Yoshiyuki ; Nakamura, Katsumasa ; Saiji, Ohga ; Nomoto, Satoshi ; Toba, Takashi ; Yoshitake, Tadamasa ; Soeda, Hiroyasu ; Terashima, Hiromi ; Honda, Hiroshi. / Adult rhabdomyosarcoma in the nasal and paranasal sinuses showing complete local response to a combination of chemotherapy and radiotherapy using 3D-CRT and IMRT. :: Fukuoka igaku zasshi = Hukuoka acta medica. 2005 ; 巻 96, 番号 10. pp. 363-369.
@article{4eefd5f4435c414daf8f5355fa0a577a,
title = "Adult rhabdomyosarcoma in the nasal and paranasal sinuses showing complete local response to a combination of chemotherapy and radiotherapy using 3D-CRT and IMRT.",
abstract = "We report on a 69-year-old woman with rhabdomyosarcoma arising from the nasal and paranasal sinuses. She was referred to our hospital with a reduced ability to smell and impaired bilateral vision, narrowing of the visual field, and left facial pain. Computed tomography (CT) revealed a large tumor in the nasal and left paranasal sinuses invading the left orbital cavity and anterior skull base, and lymph node swellings in the submental and left accessory nerve areas. A biopsy specimen from the nasal tumor was diagnosed histologically as a rhabdomyosarcoma, alveolar type. Because the intracranial direct invasion and distant metastases to the thoracic spine were suspected by pretreatment examination, our case was determined to be inoperable by a head and neck surgeon. Radiotherapy with a total dose of 60 Gy was carried out to control the primary disease. The three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) techniques were used in order to reduce the doses to risk organs. Combined with radiotherapy, chemotherapy was also performed for the treatment of lymph-node metastases and distant diseases. After the treatment was completed, the primary tumor and lymph-node metastases disappeared completely; there was no sign of re-growth during the follow-up period. Chemoradiotherapy may be an effective treatment also for inoperable adult rhabdomyosarcoma in the head and neck region. Furthermore, the 3D-CRT and IMRT techniques are both useful methods of radiotherapy for this disease.",
author = "Emi Muto and Yoshiyuki Shioyama and Katsumasa Nakamura and Ohga Saiji and Satoshi Nomoto and Takashi Toba and Tadamasa Yoshitake and Hiroyasu Soeda and Hiromi Terashima and Hiroshi Honda",
year = "2005",
month = "1",
day = "1",
language = "English",
volume = "96",
pages = "363--369",
journal = "Fukuoka Acta Medica",
issn = "0016-254X",
publisher = "福岡医学会",
number = "10",

}

TY - JOUR

T1 - Adult rhabdomyosarcoma in the nasal and paranasal sinuses showing complete local response to a combination of chemotherapy and radiotherapy using 3D-CRT and IMRT.

AU - Muto, Emi

AU - Shioyama, Yoshiyuki

AU - Nakamura, Katsumasa

AU - Saiji, Ohga

AU - Nomoto, Satoshi

AU - Toba, Takashi

AU - Yoshitake, Tadamasa

AU - Soeda, Hiroyasu

AU - Terashima, Hiromi

AU - Honda, Hiroshi

PY - 2005/1/1

Y1 - 2005/1/1

N2 - We report on a 69-year-old woman with rhabdomyosarcoma arising from the nasal and paranasal sinuses. She was referred to our hospital with a reduced ability to smell and impaired bilateral vision, narrowing of the visual field, and left facial pain. Computed tomography (CT) revealed a large tumor in the nasal and left paranasal sinuses invading the left orbital cavity and anterior skull base, and lymph node swellings in the submental and left accessory nerve areas. A biopsy specimen from the nasal tumor was diagnosed histologically as a rhabdomyosarcoma, alveolar type. Because the intracranial direct invasion and distant metastases to the thoracic spine were suspected by pretreatment examination, our case was determined to be inoperable by a head and neck surgeon. Radiotherapy with a total dose of 60 Gy was carried out to control the primary disease. The three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) techniques were used in order to reduce the doses to risk organs. Combined with radiotherapy, chemotherapy was also performed for the treatment of lymph-node metastases and distant diseases. After the treatment was completed, the primary tumor and lymph-node metastases disappeared completely; there was no sign of re-growth during the follow-up period. Chemoradiotherapy may be an effective treatment also for inoperable adult rhabdomyosarcoma in the head and neck region. Furthermore, the 3D-CRT and IMRT techniques are both useful methods of radiotherapy for this disease.

AB - We report on a 69-year-old woman with rhabdomyosarcoma arising from the nasal and paranasal sinuses. She was referred to our hospital with a reduced ability to smell and impaired bilateral vision, narrowing of the visual field, and left facial pain. Computed tomography (CT) revealed a large tumor in the nasal and left paranasal sinuses invading the left orbital cavity and anterior skull base, and lymph node swellings in the submental and left accessory nerve areas. A biopsy specimen from the nasal tumor was diagnosed histologically as a rhabdomyosarcoma, alveolar type. Because the intracranial direct invasion and distant metastases to the thoracic spine were suspected by pretreatment examination, our case was determined to be inoperable by a head and neck surgeon. Radiotherapy with a total dose of 60 Gy was carried out to control the primary disease. The three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) techniques were used in order to reduce the doses to risk organs. Combined with radiotherapy, chemotherapy was also performed for the treatment of lymph-node metastases and distant diseases. After the treatment was completed, the primary tumor and lymph-node metastases disappeared completely; there was no sign of re-growth during the follow-up period. Chemoradiotherapy may be an effective treatment also for inoperable adult rhabdomyosarcoma in the head and neck region. Furthermore, the 3D-CRT and IMRT techniques are both useful methods of radiotherapy for this disease.

UR - http://www.scopus.com/inward/record.url?scp=33644862182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644862182&partnerID=8YFLogxK

M3 - Article

C2 - 16408493

AN - SCOPUS:33644862182

VL - 96

SP - 363

EP - 369

JO - Fukuoka Acta Medica

JF - Fukuoka Acta Medica

SN - 0016-254X

IS - 10

ER -