Adult T-cell leukemia development from a human T-cell leukemia virus type I carrier after a living-donor liver transplantation

Noriaki Kawano, Kazuya Shimoda, Fumihiko Ishikawa, Akinobu Taketomi, Tomoharu Yoshizumi, Shinji Shimoda, Shuro Yoshida, Koji Uozumi, Shinsuke Suzuki, Yoshihiko Maehara, Mine Harada

研究成果: ジャーナルへの寄稿記事

56 引用 (Scopus)

抄録

Adult T-cell leukemia (ATL) develops in a human T-cell leukemia virus type I (HTLV-I) carrier. The development of malignancy during immunosuppressive treatment following organ transplantation is one of the late fatal complications. We describe the development of three cases of ATL in eight HTLV-I carriers within 164 living-donor liver transplant recipients undergoing immunosuppressive treatment. All three cases were immunosuppressed with tacrolimus. Acute-type ATL was diagnosed at 6, 9, and 25 months after living-donor liver transplantation, based on increased numbers of CD4+25+ lymphocytes exhibiting "flower-like" nuclei, and the elevation of lactate dehydrogenase. Southern blot analysis demonstrated the clonal proliferation of ATL cells in peripheral blood. The ATL cells originated from the recipient, as demonstrated by fluorescence in situ hybridization analysis using sex chromosomal markers. Our observations suggest that immunosuppressive treatment for the prevention of graft rejection after living-donor liver transplantation may induce the development of ATL in an HTLV-I carrier.

元の言語英語
ページ(範囲)840-843
ページ数4
ジャーナルTransplantation
82
発行部数6
DOI
出版物ステータス出版済み - 9 1 2006

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Adult T Cell Leukemia Lymphoma
Human T-lymphotropic virus 1
Living Donors
Liver Transplantation
Immunosuppressive Agents
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Graft Rejection
Tacrolimus
Organ Transplantation
Southern Blotting
Fluorescence In Situ Hybridization
L-Lactate Dehydrogenase
Therapeutics
Lymphocytes
Liver
Neoplasms

All Science Journal Classification (ASJC) codes

  • Transplantation

これを引用

Adult T-cell leukemia development from a human T-cell leukemia virus type I carrier after a living-donor liver transplantation. / Kawano, Noriaki; Shimoda, Kazuya; Ishikawa, Fumihiko; Taketomi, Akinobu; Yoshizumi, Tomoharu; Shimoda, Shinji; Yoshida, Shuro; Uozumi, Koji; Suzuki, Shinsuke; Maehara, Yoshihiko; Harada, Mine.

:: Transplantation, 巻 82, 番号 6, 01.09.2006, p. 840-843.

研究成果: ジャーナルへの寄稿記事

Kawano, N, Shimoda, K, Ishikawa, F, Taketomi, A, Yoshizumi, T, Shimoda, S, Yoshida, S, Uozumi, K, Suzuki, S, Maehara, Y & Harada, M 2006, 'Adult T-cell leukemia development from a human T-cell leukemia virus type I carrier after a living-donor liver transplantation', Transplantation, 巻. 82, 番号 6, pp. 840-843. https://doi.org/10.1097/01.tp.0000235186.30113.c7
Kawano, Noriaki ; Shimoda, Kazuya ; Ishikawa, Fumihiko ; Taketomi, Akinobu ; Yoshizumi, Tomoharu ; Shimoda, Shinji ; Yoshida, Shuro ; Uozumi, Koji ; Suzuki, Shinsuke ; Maehara, Yoshihiko ; Harada, Mine. / Adult T-cell leukemia development from a human T-cell leukemia virus type I carrier after a living-donor liver transplantation. :: Transplantation. 2006 ; 巻 82, 番号 6. pp. 840-843.
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AU - Yoshizumi, Tomoharu

AU - Shimoda, Shinji

AU - Yoshida, Shuro

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AU - Maehara, Yoshihiko

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