Advance of genetics in multiple sclerosis

Takuya Matsushita

    研究成果: ジャーナルへの寄稿総説査読


    Multiple sclerosis (MS) is characterized by temporal and spatial dissemination of demyelination in the central nervous system and the pathogenesis results from both genetic and environmental factors. Elaborate surveys have revealed familial accumulation of MS and provide unequivocal evidence that genetic factors contribute to the susceptibility. Family studies strongly suggest a polygenic model of inheritance explained by relatively common allelic variants. The major histocompatibility complex (MHC) in chromosome 6p21.3 has been identified as a genetic risk locus for MS from 1970s, but it was not until genome wide association studies (GWAS) were conducted in MS that genetic risks outside of MHC were identified. International collaboration and the development of new laboratory and analytical methods enabled detection of risk loci with comparably low effect size. Currently, more than 100 risk loci outside of MHC were identified. However, the heritability is not fully explained by the genetic risks that have been identified by GWAS. The knowledge of genetic effects on clinical phenotype is also incomplete.

    ジャーナルClinical and Experimental Neuroimmunology
    出版ステータス出版済み - 12月 1 2015

    !!!All Science Journal Classification (ASJC) codes

    • 神経科学(その他)
    • 免疫学
    • 免疫学および微生物学(その他)
    • 臨床神経学


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