Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems

Masatoshi Maeki, Niko Kimura, Yusuke Sato, Hideyoshi Harashima, Manabu Tokeshi

研究成果: ジャーナルへの寄稿総説査読

140 被引用数 (Scopus)

抄録

Lipid-based nanobiomaterials as liposomes and lipid nanoparticles (LNPs) are the most widely used nanocarriers for drug delivery systems (DDSs). Extracellular vesicles (EVs) and exosomes are also expected to be applied as DDS nanocarriers. The performance of nanomedicines relies on their components such as lipids, targeting ligands, encapsulated DNA, encapsulated RNA, and drugs. Recently, the importance of the nanocarrier sizes smaller than 100 nm is attracting attention as a means to improve nanomedicine performance. Microfluidics and lab-on-a chip technologies make it possible to produce size-controlled LNPs by a simple continuous flow process and to separate EVs from blood samples by using a surface marker, ligand, or electric charge or by making a mass or particle size discrimination. Here, we overview recent advances in microfluidic devices and techniques for liposomes, LNPs, and EVs and their applications for DDSs.

本文言語英語
ページ(範囲)84-100
ページ数17
ジャーナルAdvanced Drug Delivery Reviews
128
DOI
出版ステータス出版済み - 3月 15 2018
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 薬科学

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