Advantage of having regulatory T cells requires localized suppression of immune reactions

Koichi Saeki, Yoh Iwasa

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

The immune system of vertebrates may attack its own body and cause autoimmunity diseases. To prevent autoimmunity, regulatory T cells suppress the activity of the autoreactive effector T cells, but they also interrupt normal immune reactions against foreign antigens. In this paper, we discuss the advantage of having some regulatory T cells by considering the host's ability of coping with foreign antigens and the harm of autoimmunity. Assumptions are as follows: the immature T cells reactive to abundant self-antigens are eliminated, those reactive to rare self-antigen will become regulatory T cells, and those that fail to interact with the antigens to which they are reactive will become effector T cells. Some self-reactive immature T cells may fail to interact with their own target antigens during the limited training period, and will later become effector T cells, causing autoimmunity. Analysis suggests that, having some regulatory T cells can never be advantageous to the host, if activated regulatory T cells suppress effector T cells at any location of the body (global suppression). In contrast, producing some regulatory T cells can be beneficial, if the body is composed of many compartments and regulatory T cells suppress the immune reactions only within the same compartment (localized suppression). This requires regulatory T cells to stop circulating once they are activated by their own target self-antigens.

本文言語英語
ページ(範囲)392-401
ページ数10
ジャーナルJournal of Theoretical Biology
260
3
DOI
出版ステータス出版済み - 10月 7 2009

!!!All Science Journal Classification (ASJC) codes

  • 医学(全般)
  • 免疫学および微生物学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 農業および生物科学(全般)
  • モデリングとシミュレーション
  • 統計学および確率
  • 応用数学

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