Affected sib pair method for searching major gene in multifactorial disease

Norikazu Yasuda, Takehiko Sasazuki

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

The affected sib pair method to detect the effect of HLA-linked disease genes has been explained from a practical viewpoint. It is based on the assumption that HLA haplotypes as marker are used to trace the inheritance pattern of closely linked disease susceptibility genes. Looking at families in which two or more siblings had disease in question, the nonrandom zygotic assortment of HLA haplotypes would be a demonstration of disease gene. Application of affected sib pair method to Graves' disease had delineated that two genes, HLA-lined and Gm-linked, are responsible for manifestation of the disease as recessive inheritance with high penetrance.

本文言語英語
ページ(範囲)295-311
ページ数17
ジャーナルThe Japanese Journal of Human Genetics
27
4
DOI
出版ステータス出版済み - 12 1982
外部発表はい

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)

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