TY - JOUR
T1 - Age and allogeneic hematopoietic cell transplantation outcomes in acute myeloid leukemia
AU - Yanada, Masamitsu
AU - Yamasaki, Satoshi
AU - Konuma, Takaaki
AU - Mizuno, Shohei
AU - Uchida, Naoyuki
AU - Onai, Daishi
AU - Fukuda, Takahiro
AU - Tanaka, Masatsugu
AU - Ozawa, Yukiyasu
AU - Eto, Tetsuya
AU - Ikegame, Kazuhiro
AU - Sawa, Masashi
AU - Katayama, Yuta
AU - Kawakita, Toshiro
AU - Onizuka, Makoto
AU - Kanda, Yoshinobu
AU - Ichinohe, Tatsuo
AU - Atsuta, Yoshiko
AU - Yano, Shingo
N1 - Funding Information:
This work was supported in part by a grant from the Practical Research Project for Allergic Diseases and Immunology (Research Technology of Medical Transplantation) from the Japan Agency for Medical Research and Development (AMED), grant number: 19ek0510023h0003 (YA).
Publisher Copyright:
© 2022, Japanese Society of Hematology.
PY - 2022
Y1 - 2022
N2 - Although several studies have reported significant effects of patient age on outcomes of allogeneic hematopoietic cell transplantation (HCT), the prognostic relevance of age must be determined separately for myeloablative conditioning (MAC) and reduced-intensity conditioning (RIC). We analyzed Japanese nationwide transplantation registry data of patients aged 20–79 years with acute myeloid leukemia who underwent allogeneic HCT using MAC (n = 7525) or RIC (n = 3154) between 2008 and 2019. Patient were divided into six groups by age, with each group representing a decade, and overall survival (OS), relapse, and non-relapse mortality (NRM) were compared between adjacent age groups. The adverse impact of age on OS increased each decade starting at age 40 among patients receiving MAC, but only differed significantly between patients in their 50s and 60s among those receiving RIC. In patients receiving both MAC and RIC, the detrimental effect of advanced age on OS was accompanied by an increased risk of NRM. These findings show that age affects NRM and OS significantly, but differs depending on conditioning intensity. RIC mitigates the adverse prognostic impact of older age and is thus considered a reasonable option for older patients.
AB - Although several studies have reported significant effects of patient age on outcomes of allogeneic hematopoietic cell transplantation (HCT), the prognostic relevance of age must be determined separately for myeloablative conditioning (MAC) and reduced-intensity conditioning (RIC). We analyzed Japanese nationwide transplantation registry data of patients aged 20–79 years with acute myeloid leukemia who underwent allogeneic HCT using MAC (n = 7525) or RIC (n = 3154) between 2008 and 2019. Patient were divided into six groups by age, with each group representing a decade, and overall survival (OS), relapse, and non-relapse mortality (NRM) were compared between adjacent age groups. The adverse impact of age on OS increased each decade starting at age 40 among patients receiving MAC, but only differed significantly between patients in their 50s and 60s among those receiving RIC. In patients receiving both MAC and RIC, the detrimental effect of advanced age on OS was accompanied by an increased risk of NRM. These findings show that age affects NRM and OS significantly, but differs depending on conditioning intensity. RIC mitigates the adverse prognostic impact of older age and is thus considered a reasonable option for older patients.
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U2 - 10.1007/s12185-022-03486-7
DO - 10.1007/s12185-022-03486-7
M3 - Article
AN - SCOPUS:85141374724
SN - 0925-5710
JO - International Journal of Hematology
JF - International Journal of Hematology
ER -