Age-dependent changes in cell proliferation and cell death in the periodontal tissue and the submandibular gland in mice: A comparison with other tissues and organs

Norio Enoki, Tamotsu Kiyoshima, Takako Sakai, Ieyoshi Kobayashi, Keiko Takahashi, Yoshihiro Terada, Hidetaka Sakai

研究成果: Contribution to journalArticle査読

15 被引用数 (Scopus)

抄録

This study investigated the age-dependent changes in the number of BrdU- and TUNEL-positive cells in murine gingival tissue and submandibular gland, and compared the findings with those in other tissues and organs. The cell proliferative activity was decreased after 20 weeks of age in epithelial cells of the gingiva, tongue, buccal mucosa and skin. A decreased cell proliferative activity was also associated with aging in the liver and kidney parenchymal cells. Meanwhile, cell death showed peculiar changes in gingival subepithelial tissue, and mucous and serous acini of the submandibular gland. An increase of TUNEL-positive cells was demonstrated in gingival subepithelial tissue after 20-week-old of age. A significant increase of TUNEL-positive cells was also found in the mucous acinar cells in the 20-week-old mice and in the serous acini after 20 weeks. The fluctuation in the number of TUNEL-positive cells in the subepithelial tissue of the skin, and BrdU- and TUNEL-positive staining ratios in the liver was smaller than that in other tissue and organs throughout life. This study may provide useful information for better understanding the influence of aging on the functional alteration that occurs in the gingival tissue and submandibular gland of the elderly.

本文言語英語
ページ(範囲)321-332
ページ数12
ジャーナルJournal of Molecular Histology
38
4
DOI
出版ステータス出版済み - 8 2007

All Science Journal Classification (ASJC) codes

  • 組織学
  • 生理学
  • 細胞生物学

フィンガープリント

「Age-dependent changes in cell proliferation and cell death in the periodontal tissue and the submandibular gland in mice: A comparison with other tissues and organs」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル