Age-related changes in subtelomeric methylation in the normal Japanese population

Toyoki Maeda, Zhi Guan Jing, Jun Ichi Oyama, Yoshihiro Higuchi, Naoki Makino

研究成果: Contribution to journalArticle査読

25 被引用数 (Scopus)

抄録

Background. The telomeres of somatic cells become shorter with individual aging. However, no significant change in subtelomeric methylation of somatic cells with aging has yet been reported. Methods. Telomere lengths of the peripheral blood cells of 148 normal Japanese were analyzed by Southern blotting using methylation-sensitive and -insensitive isoschizomers. Results. With aging, long telomeres decrease and short telomeres increase, and the contents of the telomeres with methylated subtelomere increase in long telomeres, thus leading us to postulate that telomeres with less methylated subtelomeres tend to become shortened faster. Conclusions. A telomere length distribution analysis with methylation-sensitive and -insensitive isoschizomer seems to be a useful tool to assess the subtelomeric methylation status of the somatic cell population. The subtelomeric methylation of peripheral blood cells is also indicated to be an indicator for aging-associated genomic changes.

本文言語英語
ページ(範囲)426-434
ページ数9
ジャーナルJournals of Gerontology - Series A Biological Sciences and Medical Sciences
64
4
DOI
出版ステータス出版済み - 4 2009

All Science Journal Classification (ASJC) codes

  • 加齢科学
  • 老年医学

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