Age-related decrease in the antiseizure effect of ifenprodil against pentylenetetrazole in mice

Makoto Tsuda, Tsutomu Suzuki, Miwa Misawa

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)

抄録

The developmental change in the antiseizure effect of ifenprodil against pentylenetetrazole (PTZ) was examined in mice. Ifenprodil (i.p.) significantly increased the latency to seizure induced by PTZ in 7- and 10- day-old mice, but not in 14- or 21-day-old mice. Intracerebroventricular administration of ifenprodil also failed to modify the latency to PTZ- induced seizure in 21-day-old mice. Dizocilpine produced an increase in the latency to PTZ-induced seizure in 7- and 21-day-old mice. In an NMDA receptor binding assay using [3H]dizocilpine, ifenprodil was clearly more potent in inhibiting [3H]dizocilpine binding in a forebrain membrane preparation from 7- rather than 21-day-old mice. These results suggest that the remarkable antiseizure effect of ifenprodil against PTZ in 7-day-old mice may be related to the high proportion of ifenprodil-sensitive NMDA receptors in the brain.

本文言語英語
ページ(範囲)201-204
ページ数4
ジャーナルDevelopmental Brain Research
104
1-2
DOI
出版ステータス出版済み - 12 19 1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • 発達神経科学
  • 発生生物学

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