抄録
Background: The characteristics of electroencephalogram (EEG) profiles under general anesthesia may depend on age and type of anesthetic. Aim: This study investigated age-related differences in EEG waveforms between three inhalational anesthetics used at the same minimum alveolar concentration (MAC), which indicates the level of analgesia. Methods: Patients with American Society of Anesthesiologists physical status I–II were divided into three groups according to age: pediatric (≦ 15 years); adult (16–64 years); and elderly (≧ 65 years). Each group was divided into three subgroups according to the inhalational anesthetic used: sevoflurane, isoflurane, and desflurane. Anesthesia was maintained at 1 MAC, followed by assessment of 95% spectral edge frequency (SEF95) values and amplitude of EEG waveform. Results: The 3 age groups comprised a total of 180 patients. The mean (± SD) EEG waveform amplitude and SEF95 values for sevoflurane in the pediatric, adult, and elderly age groups, respectively, were: 32.9 ± 2.9 µV and 16.7 ± 2.4 Hz; 16.4 ± 3.6 µV and 12.2 ± 1.3 Hz; and 11.0 ± 2.1 µV and 13.6 ± 1.6 Hz. EEG waveform amplitude and SEF95 values were significantly higher in the pediatric group than in the other groups. SEF95 value was higher in the elderly group than in the adult group. Similar results were obtained for isoflurane and desflurane. Conclusion: The amplitude of the EEG waveform and SEF95 values varied with age, even at the same analgesic state in patients under general anesthesia. This age-dependent change in EEG waveform was observed for all three inhalational anesthetics, and should be considered in procedures requiring general anesthesia.
| 元の言語 | 英語 |
|---|---|
| ジャーナル | Aging Clinical and Experimental Research |
| DOI | |
| 出版物ステータス | 受理済み/印刷中 - 1 1 2019 |
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All Science Journal Classification (ASJC) codes
- Ageing
- Geriatrics and Gerontology
これを引用
Age-related effects of three inhalational anesthetics at one minimum alveolar concentration on electroencephalogram waveform. / Tsukamoto, Masanori; Taura, Shiori; Yamanaka, Hitoshi; Hitosugi, Takashi; Kawakubo, Yoshifumi; Yokoyama, Takeshi.
：: Aging Clinical and Experimental Research, 01.01.2019.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Age-related effects of three inhalational anesthetics at one minimum alveolar concentration on electroencephalogram waveform
AU - Tsukamoto, Masanori
AU - Taura, Shiori
AU - Yamanaka, Hitoshi
AU - Hitosugi, Takashi
AU - Kawakubo, Yoshifumi
AU - Yokoyama, Takeshi
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: The characteristics of electroencephalogram (EEG) profiles under general anesthesia may depend on age and type of anesthetic. Aim: This study investigated age-related differences in EEG waveforms between three inhalational anesthetics used at the same minimum alveolar concentration (MAC), which indicates the level of analgesia. Methods: Patients with American Society of Anesthesiologists physical status I–II were divided into three groups according to age: pediatric (≦ 15 years); adult (16–64 years); and elderly (≧ 65 years). Each group was divided into three subgroups according to the inhalational anesthetic used: sevoflurane, isoflurane, and desflurane. Anesthesia was maintained at 1 MAC, followed by assessment of 95% spectral edge frequency (SEF95) values and amplitude of EEG waveform. Results: The 3 age groups comprised a total of 180 patients. The mean (± SD) EEG waveform amplitude and SEF95 values for sevoflurane in the pediatric, adult, and elderly age groups, respectively, were: 32.9 ± 2.9 µV and 16.7 ± 2.4 Hz; 16.4 ± 3.6 µV and 12.2 ± 1.3 Hz; and 11.0 ± 2.1 µV and 13.6 ± 1.6 Hz. EEG waveform amplitude and SEF95 values were significantly higher in the pediatric group than in the other groups. SEF95 value was higher in the elderly group than in the adult group. Similar results were obtained for isoflurane and desflurane. Conclusion: The amplitude of the EEG waveform and SEF95 values varied with age, even at the same analgesic state in patients under general anesthesia. This age-dependent change in EEG waveform was observed for all three inhalational anesthetics, and should be considered in procedures requiring general anesthesia.
AB - Background: The characteristics of electroencephalogram (EEG) profiles under general anesthesia may depend on age and type of anesthetic. Aim: This study investigated age-related differences in EEG waveforms between three inhalational anesthetics used at the same minimum alveolar concentration (MAC), which indicates the level of analgesia. Methods: Patients with American Society of Anesthesiologists physical status I–II were divided into three groups according to age: pediatric (≦ 15 years); adult (16–64 years); and elderly (≧ 65 years). Each group was divided into three subgroups according to the inhalational anesthetic used: sevoflurane, isoflurane, and desflurane. Anesthesia was maintained at 1 MAC, followed by assessment of 95% spectral edge frequency (SEF95) values and amplitude of EEG waveform. Results: The 3 age groups comprised a total of 180 patients. The mean (± SD) EEG waveform amplitude and SEF95 values for sevoflurane in the pediatric, adult, and elderly age groups, respectively, were: 32.9 ± 2.9 µV and 16.7 ± 2.4 Hz; 16.4 ± 3.6 µV and 12.2 ± 1.3 Hz; and 11.0 ± 2.1 µV and 13.6 ± 1.6 Hz. EEG waveform amplitude and SEF95 values were significantly higher in the pediatric group than in the other groups. SEF95 value was higher in the elderly group than in the adult group. Similar results were obtained for isoflurane and desflurane. Conclusion: The amplitude of the EEG waveform and SEF95 values varied with age, even at the same analgesic state in patients under general anesthesia. This age-dependent change in EEG waveform was observed for all three inhalational anesthetics, and should be considered in procedures requiring general anesthesia.
UR - http://www.scopus.com/inward/record.url?scp=85074436951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074436951&partnerID=8YFLogxK
U2 - 10.1007/s40520-019-01378-1
DO - 10.1007/s40520-019-01378-1
M3 - Article
C2 - 31650503
AN - SCOPUS:85074436951
JO - Aging clinical and experimental research
JF - Aging clinical and experimental research
SN - 1594-0667
ER -