Aggregation of DNA-tagged liposomes controllable by external stimuli

Mai Hiraki, Tatsuo Maruyama, Hiroshi Yamamura, Masahiro Goto

    研究成果: 書籍/レポート タイプへの寄稿会議への寄与

    抄録

    Here we describe a novel strategy of liposome aggregation employing DNA-surfactant, in which the aggregation of liposomes can be reversibly controlled by enzyme stimuli and temperature. Single-stranded oligonucleotides were tethered to the outer surface of liposomes. Mixing of the DNA-tagged liposomes with ones bearing complementary DNA strands initiated the aggregation of liposomes. The liposomes were linked with each other via duplex DNA. The aggregated liposomes were dissociated by restriction enzyme to produce the initial discrete liposomes and re-aggregated by ligase.

    本文言語英語
    ホスト出版物のタイトル54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan
    ページ2211
    ページ数1
    54
    1
    出版ステータス出版済み - 2005
    イベント54th SPSJ Annual Meeting 2005 - Yokohama, 日本
    継続期間: 5月 25 20055月 27 2005

    その他

    その他54th SPSJ Annual Meeting 2005
    国/地域日本
    CityYokohama
    Period5/25/055/27/05

    !!!All Science Journal Classification (ASJC) codes

    • 工学(全般)

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