Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: Epidemiology, clinical findings, and prevention

Masaru Morita, Ryuichi Kumashiro, Nobuhide Kubo, Yuichiro Nakashima, Rintaro Yoshida, Keiji Yoshinaga, Hiroshi Saeki, Yasunori Emi, Yoshihiro Kakeji, Yoshihisa Sakaguchi, Yasushi Toh, Yoshihiko Maehara

研究成果: Contribution to journalReview article査読

131 被引用数 (Scopus)

抄録

Both cigarette smoking and alcohol drinking are well-established risk factors for esophageal squamous cell carcinoma (ESCC), and the relationship of dose to cancer risk has already been described. Furthermore, the synergistic effect of these two factors has been reported. Our case-control study revealed the odds ratio of ESCC to be 50.1 for those who were both heavy smokers and heavy drinkers in comparison to people who neither drank nor smoked. In patients with ESCC, head and neck cancers as well as dysplastic lesions are frequently observed. Heavy smoking and heavy drinking are closely related to such multicentric carcinogenesis events in the upper aerodigestive tract (UADT), including the esophagus and head andneck region. Polymorphisms in acetaldehyde dehydrogenase 2 (ALDH2) are reported to be a key event in deciding individual susceptibility to UADT cancer. Patients with inactive ALDH2, in whom facial flushing is usually observed after the drinking of alcohol, are at high risk for ESCC as well as multiple UADT cancers. For the early detection of the disease, effective follow up using endoscopy with Lugol staining or narrow band imaging endoscopy is strongly recommended for high-risk populations, such as smokers, heavy drinkers, people with experience of flushing after the drinking of alcohol, and patients with UADT cancer.

本文言語英語
ページ(範囲)126-134
ページ数9
ジャーナルInternational Journal of Clinical Oncology
15
2
DOI
出版ステータス出版済み - 4 2010

All Science Journal Classification (ASJC) codes

  • 外科
  • 血液学
  • 腫瘍学

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