Allogeneic bone marrow and peripheral stem cell transplantation from a haplo-identical mother and CD34 positive selection for CML

K. Kato, S. Kojima, M. Kondo, J. Inaba, T. Matsuyama

研究成果: Contribution to journalArticle査読

3 被引用数 (Scopus)

抄録

A 6-year-old boy with CML in blastic crisis was transplanted with BM and PBSC from his HLA-mismatched MLC-positive mother following CD34-positive selection. Preconditioning for transplant was with thiotepa, cyclophosphamide, rabbit anti-human thymocyte globulin, and TBI followed by infusion of 2.6 x 106/kg of CD34-positive BM and PBSC. Engraftment was confirmed by FISH analysis, and GVHD was not observed. On day 50, he relapsed and died despite three transfusions of donor lymphocytes without GVHD prophylaxis. CD34-positive cell selection for HLA-mismatched transplantation may prevent severe acute GVHD.

本文言語英語
ページ(範囲)449-452
ページ数4
ジャーナルBone Marrow Transplantation
18
2
出版ステータス出版済み - 8 1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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