Allogeneic haematopoietic stem cell transplantation for infant acute lymphoblastic leukaemia with KMT2A (MLL) rearrangements: A retrospective study from the paediatric acute lymphoblastic leukaemia working group of the Japan Society for Haematopoietic Cell Transplantation

Motohiro Kato, Daiichiro Hasegawa, Katsuyoshi Koh, Keisuke Kato, Junko Takita, Jiro Inagaki, Hiromasa Yabe, Hiroaki Goto, Souichi Adachi, Akira Hayakawa, Yasufumi Takeshita, Akihisa Sawada, Yoshiko Atsuta, Koji Kato

研究成果: ジャーナルへの寄稿学術誌査読

13 被引用数 (Scopus)

抄録

Summary: Allogeneic haematopoietic stem cell transplantation (HSCT) is still considered to play an important role as a consolidation therapy for high-risk infants with acute lymphoblastic leukaemia (ALL). Here, we retrospectively analysed outcomes of HSCT in infants with ALL based on nationwide registry data of the Japan Society for Haematopoietic Cell Transplantation. A total of 132 allogeneic HSCT for infant ALL with KMT2A (MLL) gene rearrangements, which were performed in first complete remission (CR1), were analysed. The 5-year overall survival rate after transplantation was 67·4 ± 4·5%). Although recent HSCT (after 2004) had a trend toward better survival, no statistical correlation was observed between outcomes and each factor, including age at diagnosis, initial leucocyte count, cytogenetics, donor types or conditioning of HSCT. Myeloablative conditioning with total body irradiation did not provide a better survival (60·7 ± 9·2%) over that with busulfan (BU; 67·8 ± 5·7%). Two of the 28 patients treated with irradiation, but none of the 90 BU-treated patients, developed a secondary malignant neoplasm. In conclusion, allogeneic HSCT using BU was a valuable option for infant ALL with KMT2A rearrangements in CR1.

本文言語英語
ページ(範囲)564-570
ページ数7
ジャーナルBritish Journal of Haematology
168
4
DOI
出版ステータス出版済み - 2月 1 2015
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 血液学

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