Allogeneic Stem Cell Transplantation for Acute Lymphoblastic Leukemia in Adolescents and Young Adults

Mayumi Hangai, Kevin Y. Urayama, Junji Tanaka, Koji Kato, Satoshi Nishiwaki, Katsuyoshi Koh, Maiko Noguchi, Keisuke Kato, Nao Yoshida, Maho Sato, Hiroaki Goto, Yuki Yuza, Yoshiko Hashii, Yoshiko Atsuta, Shuichi Mizuta, Motohiro Kato

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Hematologic stem cell transplantation (HSCT) is the most potent consolidation therapy for high-risk acute lymphoblastic leukemia (ALL), but their outcomes and complications in adolescent and young adult (AYA) patients remain unclear. We compared outcomes after HSCT for ALL among children (age 1 to 9 years; n = 607), adolescents (age 10 to 19 years; n = 783), and young adults (age 20 to 29 years old, n = 603), based on Japanese nationwide registry data. The 5-year overall survival (OS) rate among AYA patients was worse than that of children, at 64% (95% confidence interval [CI], 60% to 68%). In the AYA, the 5-year treatment-related mortality (TRM) after HSCT was 19% (95% CI, 16% to 22%), significantly higher than that in younger patients. The most common cause of TRM in the AYA was infection. The relapse rate was not different across the 3 age groups. When focusing on older adolescents (age 15 to 19 years), there was no difference in outcomes between those treated in pediatric centers and those treated in adult centers. In conclusion, the AYA had a greater risk of nonrelapse death than younger patients, and infection was the most common cause. Further optimization is required for HSCT in AYAs with ALL.

元の言語英語
ページ(範囲)1597-1602
ページ数6
ジャーナルBiology of Blood and Marrow Transplantation
25
発行部数8
DOI
出版物ステータス出版済み - 8 2019
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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    Hangai, M., Urayama, K. Y., Tanaka, J., Kato, K., Nishiwaki, S., Koh, K., Noguchi, M., Kato, K., Yoshida, N., Sato, M., Goto, H., Yuza, Y., Hashii, Y., Atsuta, Y., Mizuta, S., & Kato, M. (2019). Allogeneic Stem Cell Transplantation for Acute Lymphoblastic Leukemia in Adolescents and Young Adults. Biology of Blood and Marrow Transplantation, 25(8), 1597-1602. https://doi.org/10.1016/j.bbmt.2019.04.014