Allograft inflammatory factor 1 is a regulator of transcytosis in M cells

Sari Kishikawa, Shintaro S.S. Sato, Satoshi Kaneto, Shigeo Uchino, Shinichi Kohsaka, Seiji Nakamura, Hiroshi Kiyono

研究成果: Contribution to journalArticle

19 引用 (Scopus)

抜粋

M cells in follicle-associated epithelium (FAE) are specialized antigen-sampling cells that take up intestinal luminal antigens. Transcription factor Spi-B regulates M-cell maturation, but the molecules that promote transcytosis within M cells are not fully identified. Here we show that mouse allograft inflammatory factor 1 (Aif1) is expressed by M cells and contributes to M-cell transcytosis. FAE in Aif1 -/- mice has suppressed uptake of particles and commensal bacteria, compared with wild-type mice. Translocation of Yersinia enterocolitica, but not of Salmonella enterica serovar Typhimurium, leading to the generation of antigen-specific IgA antibodies, is also diminished in Aif1-deficient mice. Although β1 integrin, which acts as a receptor for Y. enterocolitica via invasin protein, is expressed on the apical surface membranes of M cells, its active form is rarely found in Aif1 -/- mice. These findings show that Aif1 is important for bacterial and particle transcytosis in M cells.

元の言語英語
記事番号14509
ジャーナルNature communications
8
DOI
出版物ステータス出版済み - 2 22 2017

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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    Kishikawa, S., Sato, S. S. S., Kaneto, S., Uchino, S., Kohsaka, S., Nakamura, S., & Kiyono, H. (2017). Allograft inflammatory factor 1 is a regulator of transcytosis in M cells. Nature communications, 8, [14509]. https://doi.org/10.1038/ncomms14509