Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.

Isao Ito, S. Tanabe, A. Kohda, H. Sugiyama

研究成果: ジャーナルへの寄稿記事

239 引用 (Scopus)

抄録

1. Allosteric potentiation of the ionotropic quisqualate (iQA) receptor by a nootropic drug aniracetam (1‐p‐anisoyl‐2‐pyrrolidinone) was investigated using Xenopus oocytes injected with rat brain mRNA and rat hippocampal slices. 2. Aniracetam potentiates the iQA responses induced in Xenopus oocytes by rat brain mRNA in a reversible manner. This effect was observed above the concentrations of 0.1 mM. Kainate. N‐methyl‐D‐aspartate and gamma‐aminobutyric acid responses induced in the same oocytes were not affected. 3. The specific potentiation of iQA responses was accompanied by an increase in the conductance change of iQA and alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid (AMPA) responses, but the affinity of receptors for agonist and the ion‐selectivity of the channels (reversal potentials) were not changed. 4. Aniracetam reversibly potentiated the iQA responses recorded intracellularly from the pyramidal cells in the CA1 region of rat hippocampal slices. The excitatory postsynaptic potentials (EPSPs) in Schaffer collateral‐commissural‐CA1 synapses were also potentiated by aniracetam. 5. Population EPSPs recorded in the mossy fibre‐CA3 synapses as well as Schaffer‐commissural synapses were also potentiated by aniracetam. The amplitudes of the potentiation were not changed by the formation of long‐term potentiation.

元の言語英語
ページ(範囲)533-543
ページ数11
ジャーナルThe Journal of Physiology
424
発行部数1
DOI
出版物ステータス出版済み - 5 1 1990

Fingerprint

aniracetam
Nootropic Agents
AMPA Receptors
Quisqualic Acid
Synapses
Oocytes
Excitatory Postsynaptic Potentials
Xenopus
Hippocampal CA1 Region
Messenger RNA
Acids
Pyramidal Cells
Kainic Acid
Brain

All Science Journal Classification (ASJC) codes

  • Physiology

これを引用

Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam. / Ito, Isao; Tanabe, S.; Kohda, A.; Sugiyama, H.

:: The Journal of Physiology, 巻 424, 番号 1, 01.05.1990, p. 533-543.

研究成果: ジャーナルへの寄稿記事

Ito, Isao ; Tanabe, S. ; Kohda, A. ; Sugiyama, H. / Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam. :: The Journal of Physiology. 1990 ; 巻 424, 番号 1. pp. 533-543.
@article{f8e51ce4e2c14415aeed86f23a2e806d,
title = "Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.",
abstract = "1. Allosteric potentiation of the ionotropic quisqualate (iQA) receptor by a nootropic drug aniracetam (1‐p‐anisoyl‐2‐pyrrolidinone) was investigated using Xenopus oocytes injected with rat brain mRNA and rat hippocampal slices. 2. Aniracetam potentiates the iQA responses induced in Xenopus oocytes by rat brain mRNA in a reversible manner. This effect was observed above the concentrations of 0.1 mM. Kainate. N‐methyl‐D‐aspartate and gamma‐aminobutyric acid responses induced in the same oocytes were not affected. 3. The specific potentiation of iQA responses was accompanied by an increase in the conductance change of iQA and alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid (AMPA) responses, but the affinity of receptors for agonist and the ion‐selectivity of the channels (reversal potentials) were not changed. 4. Aniracetam reversibly potentiated the iQA responses recorded intracellularly from the pyramidal cells in the CA1 region of rat hippocampal slices. The excitatory postsynaptic potentials (EPSPs) in Schaffer collateral‐commissural‐CA1 synapses were also potentiated by aniracetam. 5. Population EPSPs recorded in the mossy fibre‐CA3 synapses as well as Schaffer‐commissural synapses were also potentiated by aniracetam. The amplitudes of the potentiation were not changed by the formation of long‐term potentiation.",
author = "Isao Ito and S. Tanabe and A. Kohda and H. Sugiyama",
year = "1990",
month = "5",
day = "1",
doi = "10.1113/jphysiol.1990.sp018081",
language = "English",
volume = "424",
pages = "533--543",
journal = "Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.

AU - Ito, Isao

AU - Tanabe, S.

AU - Kohda, A.

AU - Sugiyama, H.

PY - 1990/5/1

Y1 - 1990/5/1

N2 - 1. Allosteric potentiation of the ionotropic quisqualate (iQA) receptor by a nootropic drug aniracetam (1‐p‐anisoyl‐2‐pyrrolidinone) was investigated using Xenopus oocytes injected with rat brain mRNA and rat hippocampal slices. 2. Aniracetam potentiates the iQA responses induced in Xenopus oocytes by rat brain mRNA in a reversible manner. This effect was observed above the concentrations of 0.1 mM. Kainate. N‐methyl‐D‐aspartate and gamma‐aminobutyric acid responses induced in the same oocytes were not affected. 3. The specific potentiation of iQA responses was accompanied by an increase in the conductance change of iQA and alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid (AMPA) responses, but the affinity of receptors for agonist and the ion‐selectivity of the channels (reversal potentials) were not changed. 4. Aniracetam reversibly potentiated the iQA responses recorded intracellularly from the pyramidal cells in the CA1 region of rat hippocampal slices. The excitatory postsynaptic potentials (EPSPs) in Schaffer collateral‐commissural‐CA1 synapses were also potentiated by aniracetam. 5. Population EPSPs recorded in the mossy fibre‐CA3 synapses as well as Schaffer‐commissural synapses were also potentiated by aniracetam. The amplitudes of the potentiation were not changed by the formation of long‐term potentiation.

AB - 1. Allosteric potentiation of the ionotropic quisqualate (iQA) receptor by a nootropic drug aniracetam (1‐p‐anisoyl‐2‐pyrrolidinone) was investigated using Xenopus oocytes injected with rat brain mRNA and rat hippocampal slices. 2. Aniracetam potentiates the iQA responses induced in Xenopus oocytes by rat brain mRNA in a reversible manner. This effect was observed above the concentrations of 0.1 mM. Kainate. N‐methyl‐D‐aspartate and gamma‐aminobutyric acid responses induced in the same oocytes were not affected. 3. The specific potentiation of iQA responses was accompanied by an increase in the conductance change of iQA and alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid (AMPA) responses, but the affinity of receptors for agonist and the ion‐selectivity of the channels (reversal potentials) were not changed. 4. Aniracetam reversibly potentiated the iQA responses recorded intracellularly from the pyramidal cells in the CA1 region of rat hippocampal slices. The excitatory postsynaptic potentials (EPSPs) in Schaffer collateral‐commissural‐CA1 synapses were also potentiated by aniracetam. 5. Population EPSPs recorded in the mossy fibre‐CA3 synapses as well as Schaffer‐commissural synapses were also potentiated by aniracetam. The amplitudes of the potentiation were not changed by the formation of long‐term potentiation.

UR - http://www.scopus.com/inward/record.url?scp=0025356607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025356607&partnerID=8YFLogxK

U2 - 10.1113/jphysiol.1990.sp018081

DO - 10.1113/jphysiol.1990.sp018081

M3 - Article

C2 - 1975272

AN - SCOPUS:0025356607

VL - 424

SP - 533

EP - 543

JO - Journal of Physiology

JF - Journal of Physiology

SN - 0022-3751

IS - 1

ER -