Altered face inversion effect and association between face N170 reduction and social dysfunction in patients with schizophrenia

Tomoya Tsunoda, Shigenobu Kanba, Takefumi Ueno, Yoji Hirano, Shogo Hirano, Toshihiko Maekawa, Toshiaki Onitsuka

研究成果: ジャーナルへの寄稿学術誌査読

34 被引用数 (Scopus)

抄録

Objective: There is accumulating evidence that schizophrenics may have deficits in facial recognition, which has been related to disease-specific disturbances in normal social interaction. Neurophysiologically, face inversion results in an amplitude increase of the event-related potential (ERP) component N170. This face inversion effect (FIE) presumably reflects a disruption of face-specific configuration processing. The present study investigated FIE and the associations between social functioning and N170 in patients with schizophrenia. Methods: The subjects consisted of 15 schizophrenics and 15 controls. Event-related potentials (ERPs) to upright and inverted neutral faces and cars were recorded. The relationships between the Social Functioning Scale (SFS) scores and N170 amplitude to upright faces or cars were also evaluated. Results: Normal controls exhibited a significant FIE of the N170 amplitude, while schizophrenics showed no FIE. In both normal controls and schizophrenics, no inversion effect was observed for car stimuli. For face stimuli, schizophrenics showed significant bilateral N170 reduction; additionally, in schizophrenics, but not in controls, the SFS was significantly correlated with N170 amplitudes to upright faces. Conclusions: These results indicate face-specific configuration processing deficits and significant associations between face-N170 reduction and social dysfunction in schizophrenia. Significance: Abnormal face-specific configuration processing may underlie some of the social dysfunctions in schizophrenia.

本文言語英語
ページ(範囲)1762-1768
ページ数7
ジャーナルClinical Neurophysiology
123
9
DOI
出版ステータス出版済み - 9月 2012

!!!All Science Journal Classification (ASJC) codes

  • 感覚系
  • 神経学
  • 臨床神経学
  • 生理学(医学)

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