Altered soleus responses to magnetic stimulation in pure cerebellar ataxia

Tomomi Kurokawa-Kuroda, Katsuya Ogata, Rie Suga, Yoshinobu Goto, Takayuki Taniwaki, Jun ichi Kira, Shozo Tobimatsu

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

Objective: Transcranial magnetic stimulation (TMS) over the leg motor area elicits a soleus primary response (SPR) and a soleus late response (SLR). We evaluated the influence of the cerebellofugal pathway on the SPR and SLR in patients with 'pure' cerebellar ataxia. Methods: SPRs and SLRs were recorded from 11 healthy subjects and 9 patients with 'pure' cerebellar cortical degeneration; 5 with spinocerebellar ataxia type 6 (SCA6), and 4 with late cortical cerebellar ataxia (LCCA). In addition, three patients with localized cerebellar lesions were tested. Results: The SPR latency was significantly longer in patients than in controls, but primary responses in the tibialis anterior muscle were normal. The frequency of abnormal SLR was 38.9% in the supine position and 83.3% in the standing position. Two out of three patients with localized cerebellar lesions also showed abnormal SLR. Conclusions: Altered SPRs in patients may result from a dysfunction of the primary motor cortex caused by crossed cerebello-cerebral diaschisis. In addition, our results suggest that 'pure' cerebellar degeneration involves the mechanism responsible for evoking SLR which is related to the control of posture. Significance: SLR can be a useful neurophysiological parameter for evaluating cerebellofugal function.

本文言語英語
ページ(範囲)1198-1203
ページ数6
ジャーナルClinical Neurophysiology
118
6
DOI
出版ステータス出版済み - 6 2007

All Science Journal Classification (ASJC) codes

  • 感覚系
  • 神経学
  • 臨床神経学
  • 生理学(医学)

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