Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia

Shuichi Isomura, Ryota Hashimoto, Motoaki Nakamura, Yoji Hirano, Fumio Yamashita, Shin Jimbo, Hidenaga Yamamori, Michiko Fujimoto, Yuka Yasuda, Ryan P. Mears, Toshiaki Onitsuka

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

Abnormalities in prenatal brain development contribute to schizophrenia vulnerability. Orbitofrontal cortex sulcogyral patterns are largely determined during prenatal development, and four types of orbitofrontal cortex sulcogyral patterns have been classified in humans. Altered orbitofrontal cortex patterns have been reported in individuals with schizophrenia using magnetic resonance imaging; however, sample sizes of previous studies were small-medium effects for detection, and gender manifestation for orbitofrontal cortex sulcogyral patterns is unclear. The present study investigated orbitofrontal cortex patterns of 155 patients with schizophrenia and 375 healthy subjects. The orbitofrontal cortex sulcogyral pattern distributions of schizophrenia were significantly different compared with healthy subjects in the left hemisphere (X2 = 14.55, p = 0.002). In female schizophrenia, post-hoc analyses revealed significantly decreased Type I expression (X2 = 6.76, p = 0.009) and increased Type II expression (X2 = 11.56, p = 0.001) in the left hemisphere. The present study suggested that female schizophrenia showed altered orbitofrontal cortex patterns in the left hemisphere, which may be related to neurodevelopmental abnormality.

元の言語英語
記事番号3
ジャーナルnpj Schizophrenia
3
発行部数1
DOI
出版物ステータス出版済み - 12 1 2017

Fingerprint

Prefrontal Cortex
Schizophrenia
Healthy Volunteers
Sample Size
Magnetic Resonance Imaging
Brain

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

これを引用

Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia. / Isomura, Shuichi; Hashimoto, Ryota; Nakamura, Motoaki; Hirano, Yoji; Yamashita, Fumio; Jimbo, Shin; Yamamori, Hidenaga; Fujimoto, Michiko; Yasuda, Yuka; Mears, Ryan P.; Onitsuka, Toshiaki.

:: npj Schizophrenia, 巻 3, 番号 1, 3, 01.12.2017.

研究成果: ジャーナルへの寄稿記事

Isomura, S, Hashimoto, R, Nakamura, M, Hirano, Y, Yamashita, F, Jimbo, S, Yamamori, H, Fujimoto, M, Yasuda, Y, Mears, RP & Onitsuka, T 2017, 'Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia', npj Schizophrenia, 巻. 3, 番号 1, 3. https://doi.org/10.1038/s41537-016-0008-y
Isomura, Shuichi ; Hashimoto, Ryota ; Nakamura, Motoaki ; Hirano, Yoji ; Yamashita, Fumio ; Jimbo, Shin ; Yamamori, Hidenaga ; Fujimoto, Michiko ; Yasuda, Yuka ; Mears, Ryan P. ; Onitsuka, Toshiaki. / Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia. :: npj Schizophrenia. 2017 ; 巻 3, 番号 1.
@article{a909708fdaa64173b21e17be1b056fcd,
title = "Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia",
abstract = "Abnormalities in prenatal brain development contribute to schizophrenia vulnerability. Orbitofrontal cortex sulcogyral patterns are largely determined during prenatal development, and four types of orbitofrontal cortex sulcogyral patterns have been classified in humans. Altered orbitofrontal cortex patterns have been reported in individuals with schizophrenia using magnetic resonance imaging; however, sample sizes of previous studies were small-medium effects for detection, and gender manifestation for orbitofrontal cortex sulcogyral patterns is unclear. The present study investigated orbitofrontal cortex patterns of 155 patients with schizophrenia and 375 healthy subjects. The orbitofrontal cortex sulcogyral pattern distributions of schizophrenia were significantly different compared with healthy subjects in the left hemisphere (X2 = 14.55, p = 0.002). In female schizophrenia, post-hoc analyses revealed significantly decreased Type I expression (X2 = 6.76, p = 0.009) and increased Type II expression (X2 = 11.56, p = 0.001) in the left hemisphere. The present study suggested that female schizophrenia showed altered orbitofrontal cortex patterns in the left hemisphere, which may be related to neurodevelopmental abnormality.",
author = "Shuichi Isomura and Ryota Hashimoto and Motoaki Nakamura and Yoji Hirano and Fumio Yamashita and Shin Jimbo and Hidenaga Yamamori and Michiko Fujimoto and Yuka Yasuda and Mears, {Ryan P.} and Toshiaki Onitsuka",
year = "2017",
month = "12",
day = "1",
doi = "10.1038/s41537-016-0008-y",
language = "English",
volume = "3",
journal = "npj Schizophrenia",
issn = "2334-265X",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia

AU - Isomura, Shuichi

AU - Hashimoto, Ryota

AU - Nakamura, Motoaki

AU - Hirano, Yoji

AU - Yamashita, Fumio

AU - Jimbo, Shin

AU - Yamamori, Hidenaga

AU - Fujimoto, Michiko

AU - Yasuda, Yuka

AU - Mears, Ryan P.

AU - Onitsuka, Toshiaki

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Abnormalities in prenatal brain development contribute to schizophrenia vulnerability. Orbitofrontal cortex sulcogyral patterns are largely determined during prenatal development, and four types of orbitofrontal cortex sulcogyral patterns have been classified in humans. Altered orbitofrontal cortex patterns have been reported in individuals with schizophrenia using magnetic resonance imaging; however, sample sizes of previous studies were small-medium effects for detection, and gender manifestation for orbitofrontal cortex sulcogyral patterns is unclear. The present study investigated orbitofrontal cortex patterns of 155 patients with schizophrenia and 375 healthy subjects. The orbitofrontal cortex sulcogyral pattern distributions of schizophrenia were significantly different compared with healthy subjects in the left hemisphere (X2 = 14.55, p = 0.002). In female schizophrenia, post-hoc analyses revealed significantly decreased Type I expression (X2 = 6.76, p = 0.009) and increased Type II expression (X2 = 11.56, p = 0.001) in the left hemisphere. The present study suggested that female schizophrenia showed altered orbitofrontal cortex patterns in the left hemisphere, which may be related to neurodevelopmental abnormality.

AB - Abnormalities in prenatal brain development contribute to schizophrenia vulnerability. Orbitofrontal cortex sulcogyral patterns are largely determined during prenatal development, and four types of orbitofrontal cortex sulcogyral patterns have been classified in humans. Altered orbitofrontal cortex patterns have been reported in individuals with schizophrenia using magnetic resonance imaging; however, sample sizes of previous studies were small-medium effects for detection, and gender manifestation for orbitofrontal cortex sulcogyral patterns is unclear. The present study investigated orbitofrontal cortex patterns of 155 patients with schizophrenia and 375 healthy subjects. The orbitofrontal cortex sulcogyral pattern distributions of schizophrenia were significantly different compared with healthy subjects in the left hemisphere (X2 = 14.55, p = 0.002). In female schizophrenia, post-hoc analyses revealed significantly decreased Type I expression (X2 = 6.76, p = 0.009) and increased Type II expression (X2 = 11.56, p = 0.001) in the left hemisphere. The present study suggested that female schizophrenia showed altered orbitofrontal cortex patterns in the left hemisphere, which may be related to neurodevelopmental abnormality.

UR - http://www.scopus.com/inward/record.url?scp=85026239839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026239839&partnerID=8YFLogxK

U2 - 10.1038/s41537-016-0008-y

DO - 10.1038/s41537-016-0008-y

M3 - Article

AN - SCOPUS:85026239839

VL - 3

JO - npj Schizophrenia

JF - npj Schizophrenia

SN - 2334-265X

IS - 1

M1 - 3

ER -