抄録
Abnormalities in prenatal brain development contribute to schizophrenia vulnerability. Orbitofrontal cortex sulcogyral patterns are largely determined during prenatal development, and four types of orbitofrontal cortex sulcogyral patterns have been classified in humans. Altered orbitofrontal cortex patterns have been reported in individuals with schizophrenia using magnetic resonance imaging; however, sample sizes of previous studies were small-medium effects for detection, and gender manifestation for orbitofrontal cortex sulcogyral patterns is unclear. The present study investigated orbitofrontal cortex patterns of 155 patients with schizophrenia and 375 healthy subjects. The orbitofrontal cortex sulcogyral pattern distributions of schizophrenia were significantly different compared with healthy subjects in the left hemisphere (X2 = 14.55, p = 0.002). In female schizophrenia, post-hoc analyses revealed significantly decreased Type I expression (X2 = 6.76, p = 0.009) and increased Type II expression (X2 = 11.56, p = 0.001) in the left hemisphere. The present study suggested that female schizophrenia showed altered orbitofrontal cortex patterns in the left hemisphere, which may be related to neurodevelopmental abnormality.
| 元の言語 | 英語 |
|---|---|
| 記事番号 | 3 |
| ジャーナル | npj Schizophrenia |
| 巻 | 3 |
| 発行部数 | 1 |
| DOI | |
| 出版物ステータス | 出版済み - 12 1 2017 |
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All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
これを引用
Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia. / Isomura, Shuichi; Hashimoto, Ryota; Nakamura, Motoaki; Hirano, Yoji; Yamashita, Fumio; Jimbo, Shin; Yamamori, Hidenaga; Fujimoto, Michiko; Yasuda, Yuka; Mears, Ryan P.; Onitsuka, Toshiaki.
：: npj Schizophrenia, 巻 3, 番号 1, 3, 01.12.2017.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia
AU - Isomura, Shuichi
AU - Hashimoto, Ryota
AU - Nakamura, Motoaki
AU - Hirano, Yoji
AU - Yamashita, Fumio
AU - Jimbo, Shin
AU - Yamamori, Hidenaga
AU - Fujimoto, Michiko
AU - Yasuda, Yuka
AU - Mears, Ryan P.
AU - Onitsuka, Toshiaki
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Abnormalities in prenatal brain development contribute to schizophrenia vulnerability. Orbitofrontal cortex sulcogyral patterns are largely determined during prenatal development, and four types of orbitofrontal cortex sulcogyral patterns have been classified in humans. Altered orbitofrontal cortex patterns have been reported in individuals with schizophrenia using magnetic resonance imaging; however, sample sizes of previous studies were small-medium effects for detection, and gender manifestation for orbitofrontal cortex sulcogyral patterns is unclear. The present study investigated orbitofrontal cortex patterns of 155 patients with schizophrenia and 375 healthy subjects. The orbitofrontal cortex sulcogyral pattern distributions of schizophrenia were significantly different compared with healthy subjects in the left hemisphere (X2 = 14.55, p = 0.002). In female schizophrenia, post-hoc analyses revealed significantly decreased Type I expression (X2 = 6.76, p = 0.009) and increased Type II expression (X2 = 11.56, p = 0.001) in the left hemisphere. The present study suggested that female schizophrenia showed altered orbitofrontal cortex patterns in the left hemisphere, which may be related to neurodevelopmental abnormality.
AB - Abnormalities in prenatal brain development contribute to schizophrenia vulnerability. Orbitofrontal cortex sulcogyral patterns are largely determined during prenatal development, and four types of orbitofrontal cortex sulcogyral patterns have been classified in humans. Altered orbitofrontal cortex patterns have been reported in individuals with schizophrenia using magnetic resonance imaging; however, sample sizes of previous studies were small-medium effects for detection, and gender manifestation for orbitofrontal cortex sulcogyral patterns is unclear. The present study investigated orbitofrontal cortex patterns of 155 patients with schizophrenia and 375 healthy subjects. The orbitofrontal cortex sulcogyral pattern distributions of schizophrenia were significantly different compared with healthy subjects in the left hemisphere (X2 = 14.55, p = 0.002). In female schizophrenia, post-hoc analyses revealed significantly decreased Type I expression (X2 = 6.76, p = 0.009) and increased Type II expression (X2 = 11.56, p = 0.001) in the left hemisphere. The present study suggested that female schizophrenia showed altered orbitofrontal cortex patterns in the left hemisphere, which may be related to neurodevelopmental abnormality.
UR - http://www.scopus.com/inward/record.url?scp=85026239839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85026239839&partnerID=8YFLogxK
U2 - 10.1038/s41537-016-0008-y
DO - 10.1038/s41537-016-0008-y
M3 - Article
AN - SCOPUS:85026239839
VL - 3
JO - npj Schizophrenia
JF - npj Schizophrenia
SN - 2334-265X
IS - 1
M1 - 3
ER -