Alveolar rhabdomyosarcoma of unknown origin mimicking acute leukemia at the initial presentation

Kan Yamaguchi, Yuhki Koga, Aiko Suminoe, Yusuke Saito, Akinobu Matsuzaki, Shunsuke Kanno, Tomohito Takimoto, Masahiro Suda, Yoshinao Oda, Toshitaka Muto, Hiroshi Takatsuki, Toshiro Hara

研究成果: ジャーナルへの寄稿評論記事

10 引用 (Scopus)

抄録

A 14-year-old boy presented with a short history of general fatigue. Laboratory examination of the peripheral blood revealed white blood cells 11,300/microl, hemoglobin 10.4 g/dl, platelets 45,000/microl, fibrinogen < 50 mg/dl, fibrin/fibrinogen degradation products 536 microg/ml and lactate dehydrogenase 1,684 U/l. A bone marrow aspirate contained 89.6% of undifferentiated tumor cells. A hematological malignancy was suspected and the patient was treated with idarubicin and cytarabine. However, further examination revealed that tumor cells were positive for CD56 and lacked lineage markers of lymphoid or myeloid cells. They were positive for PAS, HHF35 and desmin, and negative for MPO. Reverse transcriptase polymerase chain reaction demonstrated PAX3/FKHR fusion transcripts, confirming the diagnosis of alveolar rhabdomyosarcoma. Radiological examination revealed only one enlarged lymph node being 1.5 cm in diameter at the paraaortic region in the abdomen, and failed to find a primary tumor. After three courses of chemotherapy containing etoposide, cyclophosphamide, pirarubicin, cisplatin and vincristine, tumor cells were eradicated from the bone marrow. The patient received an allogeneic bone marrow transplantation eight months after diagnosis, although he died of hepatic veno-occlusive disease on day 21. Alveolar rhabdomyosarcoma often develops in older children and younger adults, and its bone marrow infiltration may mimic acute leukemia.

元の言語英語
ページ(範囲)315-320
ページ数6
ジャーナル[Rinshō ketsueki] The Japanese journal of clinical hematology
48
発行部数4
出版物ステータス出版済み - 1 1 2007

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Alveolar Rhabdomyosarcoma
Leukemia
Bone Marrow
Neoplasms
Hepatic Veno-Occlusive Disease
Idarubicin
Fibrin Fibrinogen Degradation Products
Desmin
Cytarabine
Homologous Transplantation
Vincristine
Etoposide
Hematologic Neoplasms
Myeloid Cells
Reverse Transcriptase Polymerase Chain Reaction
Bone Marrow Transplantation
Abdomen
Cyclophosphamide
Fibrinogen
Cisplatin

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Alveolar rhabdomyosarcoma of unknown origin mimicking acute leukemia at the initial presentation. / Yamaguchi, Kan; Koga, Yuhki; Suminoe, Aiko; Saito, Yusuke; Matsuzaki, Akinobu; Kanno, Shunsuke; Takimoto, Tomohito; Suda, Masahiro; Oda, Yoshinao; Muto, Toshitaka; Takatsuki, Hiroshi; Hara, Toshiro.

:: [Rinshō ketsueki] The Japanese journal of clinical hematology, 巻 48, 番号 4, 01.01.2007, p. 315-320.

研究成果: ジャーナルへの寄稿評論記事

Yamaguchi, K, Koga, Y, Suminoe, A, Saito, Y, Matsuzaki, A, Kanno, S, Takimoto, T, Suda, M, Oda, Y, Muto, T, Takatsuki, H & Hara, T 2007, 'Alveolar rhabdomyosarcoma of unknown origin mimicking acute leukemia at the initial presentation', [Rinshō ketsueki] The Japanese journal of clinical hematology, 巻. 48, 番号 4, pp. 315-320.
Yamaguchi, Kan ; Koga, Yuhki ; Suminoe, Aiko ; Saito, Yusuke ; Matsuzaki, Akinobu ; Kanno, Shunsuke ; Takimoto, Tomohito ; Suda, Masahiro ; Oda, Yoshinao ; Muto, Toshitaka ; Takatsuki, Hiroshi ; Hara, Toshiro. / Alveolar rhabdomyosarcoma of unknown origin mimicking acute leukemia at the initial presentation. :: [Rinshō ketsueki] The Japanese journal of clinical hematology. 2007 ; 巻 48, 番号 4. pp. 315-320.
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abstract = "A 14-year-old boy presented with a short history of general fatigue. Laboratory examination of the peripheral blood revealed white blood cells 11,300/microl, hemoglobin 10.4 g/dl, platelets 45,000/microl, fibrinogen < 50 mg/dl, fibrin/fibrinogen degradation products 536 microg/ml and lactate dehydrogenase 1,684 U/l. A bone marrow aspirate contained 89.6{\%} of undifferentiated tumor cells. A hematological malignancy was suspected and the patient was treated with idarubicin and cytarabine. However, further examination revealed that tumor cells were positive for CD56 and lacked lineage markers of lymphoid or myeloid cells. They were positive for PAS, HHF35 and desmin, and negative for MPO. Reverse transcriptase polymerase chain reaction demonstrated PAX3/FKHR fusion transcripts, confirming the diagnosis of alveolar rhabdomyosarcoma. Radiological examination revealed only one enlarged lymph node being 1.5 cm in diameter at the paraaortic region in the abdomen, and failed to find a primary tumor. After three courses of chemotherapy containing etoposide, cyclophosphamide, pirarubicin, cisplatin and vincristine, tumor cells were eradicated from the bone marrow. The patient received an allogeneic bone marrow transplantation eight months after diagnosis, although he died of hepatic veno-occlusive disease on day 21. Alveolar rhabdomyosarcoma often develops in older children and younger adults, and its bone marrow infiltration may mimic acute leukemia.",
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AU - Yamaguchi, Kan

AU - Koga, Yuhki

AU - Suminoe, Aiko

AU - Saito, Yusuke

AU - Matsuzaki, Akinobu

AU - Kanno, Shunsuke

AU - Takimoto, Tomohito

AU - Suda, Masahiro

AU - Oda, Yoshinao

AU - Muto, Toshitaka

AU - Takatsuki, Hiroshi

AU - Hara, Toshiro

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N2 - A 14-year-old boy presented with a short history of general fatigue. Laboratory examination of the peripheral blood revealed white blood cells 11,300/microl, hemoglobin 10.4 g/dl, platelets 45,000/microl, fibrinogen < 50 mg/dl, fibrin/fibrinogen degradation products 536 microg/ml and lactate dehydrogenase 1,684 U/l. A bone marrow aspirate contained 89.6% of undifferentiated tumor cells. A hematological malignancy was suspected and the patient was treated with idarubicin and cytarabine. However, further examination revealed that tumor cells were positive for CD56 and lacked lineage markers of lymphoid or myeloid cells. They were positive for PAS, HHF35 and desmin, and negative for MPO. Reverse transcriptase polymerase chain reaction demonstrated PAX3/FKHR fusion transcripts, confirming the diagnosis of alveolar rhabdomyosarcoma. Radiological examination revealed only one enlarged lymph node being 1.5 cm in diameter at the paraaortic region in the abdomen, and failed to find a primary tumor. After three courses of chemotherapy containing etoposide, cyclophosphamide, pirarubicin, cisplatin and vincristine, tumor cells were eradicated from the bone marrow. The patient received an allogeneic bone marrow transplantation eight months after diagnosis, although he died of hepatic veno-occlusive disease on day 21. Alveolar rhabdomyosarcoma often develops in older children and younger adults, and its bone marrow infiltration may mimic acute leukemia.

AB - A 14-year-old boy presented with a short history of general fatigue. Laboratory examination of the peripheral blood revealed white blood cells 11,300/microl, hemoglobin 10.4 g/dl, platelets 45,000/microl, fibrinogen < 50 mg/dl, fibrin/fibrinogen degradation products 536 microg/ml and lactate dehydrogenase 1,684 U/l. A bone marrow aspirate contained 89.6% of undifferentiated tumor cells. A hematological malignancy was suspected and the patient was treated with idarubicin and cytarabine. However, further examination revealed that tumor cells were positive for CD56 and lacked lineage markers of lymphoid or myeloid cells. They were positive for PAS, HHF35 and desmin, and negative for MPO. Reverse transcriptase polymerase chain reaction demonstrated PAX3/FKHR fusion transcripts, confirming the diagnosis of alveolar rhabdomyosarcoma. Radiological examination revealed only one enlarged lymph node being 1.5 cm in diameter at the paraaortic region in the abdomen, and failed to find a primary tumor. After three courses of chemotherapy containing etoposide, cyclophosphamide, pirarubicin, cisplatin and vincristine, tumor cells were eradicated from the bone marrow. The patient received an allogeneic bone marrow transplantation eight months after diagnosis, although he died of hepatic veno-occlusive disease on day 21. Alveolar rhabdomyosarcoma often develops in older children and younger adults, and its bone marrow infiltration may mimic acute leukemia.

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