Amantadine usage for influenza A during an influenza outbreak in a nursing home

H. Ikematsu, A. Nabeshima, C. Yong, W. Li, W. Kajiyama, H. Hara, J. Hayashi, S. Kashiwagi

研究成果: Contribution to journalArticle

抄録

An outbreak of an influenza like illness was found in a nursing home in Fukuoka in January, 1999. Results of hemagglutinin inhibition tests with paired sera of patients and rapid diagnosis kit for influenza A indicated that an influenza A (H3N2) outbreak had occurred. A total of 15 patients with influenza like illness from one residential area of the nursing home were administered amantadine, 100 mg per day for five days. Clinical records of 264 residents were surveyed retrospectively from the tenth to the thirty-first of January, 1999. Influenza like illness was found in 112 residents (42.4%). The incidence of influenza like illness differed by residential area, ranging from 27.6% to 54.0%. The mean duration of fever was 3.6 days among patients administered amantadine. The mean duration was 4.4 days for patients not administered amantadine. The incidence of influenza like illness decreased rapidly after amantadine administration in the residential area where amantadine administration was done. These results suggest that amantadine is effective in mitigating influenza symptoms in the elderly. Amantadine may be useful for diminishing the influence of influenza A outbreaks in nursing homes.

元の言語英語
ページ(範囲)476-480
ページ数5
ジャーナルKansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
74
発行部数5
DOI
出版物ステータス出版済み - 5 2000
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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